Methyl CpG binding protein
From Proteopedia
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• '''MBD3''' binds to hydroxymethylated DNA.<br /> | • '''MBD3''' binds to hydroxymethylated DNA.<br /> | ||
• '''MBD4''' has a G:T mispair-specific activity.<br /> | • '''MBD4''' has a G:T mispair-specific activity.<br /> | ||
| - | • '''Methyl CpG binding protein 2''' (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see [[Methyl CpG Binding Protein 2]].<br /> | + | • '''Methyl CpG binding protein 2''' (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see [[Methyl CpG Binding Protein 2]] and [[Rett Syndrome Protein]].<br /> |
== Disease == | == Disease == | ||
Current revision
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References
- ↑ Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:http://dx.doi.org/10.1002/bies.10008
- ↑ Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
- ↑ Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res. 2012 Jun 27. PMID:22740654 doi:10.1093/nar/gks628
