6s21
From Proteopedia
(Difference between revisions)
m (Protected "6s21" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)== | |
| - | + | <StructureSection load='6s21' size='340' side='right'caption='[[6s21]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S21 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s21 OCA], [http://pdbe.org/6s21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s21 RCSB], [http://www.ebi.ac.uk/pdbsum/6s21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s21 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ENDSF_BACTN ENDSF_BACTN]] Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).<ref>PMID:25002587</ref> <ref>PMID:25002587</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Basle, A]] | ||
[[Category: Cartmell, A]] | [[Category: Cartmell, A]] | ||
| + | [[Category: Henrissat, B]] | ||
| + | [[Category: Ndeh, D]] | ||
[[Category: Strahl, H]] | [[Category: Strahl, H]] | ||
| - | [[Category: Henrissat, B]] | ||
[[Category: Terrapon, N]] | [[Category: Terrapon, N]] | ||
| - | [[Category: | + | [[Category: Cazyme]] |
| - | [[Category: | + | [[Category: Glycobiology]] |
| + | [[Category: Glycosaminoglycan]] | ||
| + | [[Category: Gut microbiota]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 08:08, 5 February 2020
Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)
| |||||||||||
