Thymidylate synthase

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== Structural highlights ==
== Structural highlights ==
TS <scene name='49/493689/Cv/4'>active site contains the substrate dUMP</scene><ref>PMID:9053905</ref>. Water molecules are shown as red spheres.
TS <scene name='49/493689/Cv/4'>active site contains the substrate dUMP</scene><ref>PMID:9053905</ref>. Water molecules are shown as red spheres.
 +
==3D structures of thymidylate synthase==
 +
[[Thymidylate synthase 3D structures]]
 +
</StructureSection>
</StructureSection>
Line 17: Line 20:
*'''Thymidylate synthase'''
*'''Thymidylate synthase'''
 +
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
 +
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
 +
**[[3ihi]], [[6qyj]] – mTS – mouse<br />
 +
**[[4iqb]] – nTS – nematode<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
Line 23: Line 30:
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
-
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]] - hTS – human<br />
 
-
**[[3n5g]], [[4kpw]] – hTS His-tag<br />
 
-
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]] – hTS (mutant)<br />
 
**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
-
**[[3ihi]] – mTS – mouse<br />
 
**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
-
**[[3ge9]], [[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
+
**[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
-
**[[4iqb]] – nTS – nematode<br />
+
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
Line 37: Line 39:
*Thymidylate synthase binary complex
*Thymidylate synthase binary complex
 +
**[[6qsh]] - hTS + dUMP<br />
 +
**[[3hb8]] - hTS (mutant) + UMP
 +
**[[6qxg]] - hTS + fluoro-dUMP<br />
 +
**[[3h9k]] - hTS (mutant) + fluoro-dUMP
 +
**[[5wrn]] - hTS + CMP<br />
 +
**[[3ob7]] - hTS (mutant) + glutathione<br />
 +
**[[4g2o]] – hTS (mutant) + purpurogallin<br />
 +
**[[4gd7]] – hTS + purpurogallin<br />
 +
**[[4g6w]] – hTS (mutant) + bromobenzine-triol<br />
 +
**[[3n5e]], [[4fgt]] - hTS + peptide inhibitor<br />
 +
**[[4e28]] - hTS + inhibitor<br />
 +
**[[6r2e]] – hTS (mutant) + folate derivative<br />
 +
**[[4e5o]] - mTS + UMP<br />
 +
**[[4ein]] – mTS + substrate analog<br />
 +
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
 +
**[[4psg]] – nTS + inhibitor <br >
 +
**[[4irr]], [[4isw]] – nTS + UMP<br />
 +
**[[5by6]] – TwTS + UMP – Trichina worm<br />
 +
**[[1tmk]] - TS + TMP – yeast<br />
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
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**[[3b9h]] - EcTS + nitro-UMP<BR />
**[[3b9h]] - EcTS + nitro-UMP<BR />
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
-
**[[1tmk]] - TS + TMP – yeast<br />
 
-
**[[3h9k]] - hTS (mutant) + fluoro-UMP<BR />
 
-
**[[3hb8]] - hTS (mutant) + UMP<BR />
 
-
**[[5wrn]] - hTS + CMP<br />
 
-
**[[3ob7]] - hTS (mutant) + glutathione<br />
 
-
**[[4g2o]] – hTS (mutant) + purpurogallin<br />
 
-
**[[4gd7]] – hTS + purpurogallin<br />
 
-
**[[4g6w]] – hTS (mutant) + bromobenzine-triol<br />
 
-
**[[3n5e]], [[4fgt]] - hTS + peptide inhibitor<br />
 
-
**[[4e28]] - hTS + inhibitor<br />
 
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
-
**[[4e5o]] - mTS + UMP<BR />
 
-
**[[4ein]] – mTS + substrate analog<br />
 
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
 +
**[[6qya]] – EfTS + dUMP<br />
**[[5j7w]] – EfTS + drug <br >
**[[5j7w]] – EfTS + drug <br >
-
**[[4psg]] – nTS + inhibitor <br >
 
-
**[[5by6]] – TS + UMP – ''Trichinella spiralis''<br />
 
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
-
**[[3fnn]] - CgTS + FAD <br />
 
**[[4h0u]] – CgTS + UMP<br />
**[[4h0u]] – CgTS + UMP<br />
-
**[[4irr]], [[4isw]] – nTS + UMP<br />
 
**[[4xsc]] - VvTS + d-Uridine derivative <br />
**[[4xsc]] - VvTS + d-Uridine derivative <br />
**[[4xsd]] - VvTS + dUMP<br />
**[[4xsd]] - VvTS + dUMP<br />
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*Thymidylate synthase ternary complex
*Thymidylate synthase ternary complex
 +
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br />
 +
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
 +
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
 +
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
 +
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
 +
**[[4eb4 - mTS + drug + UMP<br />
 +
**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
 +
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
 +
**[[4iqq]] – nTS + UMP + drug<br />
 +
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
 +
**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
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**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
-
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
 
-
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<BR />
 
-
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<BR />
 
-
**[[5hs3]] - hTS + inhibitor + UMP<br />
 
-
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor+ UMP<BR />
 
-
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis enegans''<br />
 
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
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**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
-
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
 
-
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
 
-
**[[4eb4]] - mTS + drug + UMP<BR />
 
-
**[[4iqq]] – nTS + UMP + drug<br />
 
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
 +
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
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**[[2af6]], [[3gwc]] - MtTS + FAD + halo-UMP<BR />
**[[2af6]], [[3gwc]] - MtTS + FAD + halo-UMP<BR />
**[[3hzg]] - MtTS + FAD <br />
**[[3hzg]] - MtTS + FAD <br />
 +
**[[2gq2]] - MtTS (mutant) + NADP<br />
**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
-
**[[2gq2]] - MtTS (mutant) + NADP<br />
 
**[[5jfe]] - TmTS + FAD + UMP – ''Thermotoga maritima''<br />
**[[5jfe]] - TmTS + FAD + UMP – ''Thermotoga maritima''<br />
**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP <br />
**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP <br />
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**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
**[[1o2b]] – TmTS + FAD + phosphate<br />
**[[1o2b]] – TmTS + FAD + phosphate<br />
-
**[[4gta]] – TmTS + FAD + UMP + folinic acid<br />
+
**[[4gta]] – TmTS + FAD + UMP + folate derivative<br />
**[[4gt9]] – TmTS + FAD + UMP + folate<br />
**[[4gt9]] – TmTS + FAD + UMP + folate<br />
**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
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**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
-
**[[3ge9]] - CgTS – ''Corynebacterium glutamicum''<br />
+
**[[3ge9]] - CgTS<br />
**[[3fnn]] - CgTS + FAD <br />
**[[3fnn]] - CgTS + FAD <br />
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
**[[4p5a]], [[4p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
**[[4p5a]], [[4p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
 +
**[[6j61]] - TS + FAD – ''Thermus thermophilus''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:38, 26 February 2020

Thymidylate synthase complex with dUMP (PDB entry 1tsv)

Drag the structure with the mouse to rotate

3D structures of thymidylate synthase

Updated on 26-February-2020 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Thymidylate synthase
  • Thymidylate synthase binary complex
    • 6qsh - hTS + dUMP
    • 3hb8 - hTS (mutant) + UMP
    • 6qxg - hTS + fluoro-dUMP
    • 3h9k - hTS (mutant) + fluoro-dUMP
    • 5wrn - hTS + CMP
    • 3ob7 - hTS (mutant) + glutathione
    • 4g2o – hTS (mutant) + purpurogallin
    • 4gd7 – hTS + purpurogallin
    • 4g6w – hTS (mutant) + bromobenzine-triol
    • 3n5e, 4fgt - hTS + peptide inhibitor
    • 4e28 - hTS + inhibitor
    • 6r2e – hTS (mutant) + folate derivative
    • 4e5o - mTS + UMP
    • 4ein – mTS + substrate analog
    • 4ez8 – mTS + substrate analog + dihydrofolate
    • 4psg – nTS + inhibitor
    • 4irr, 4isw – nTS + UMP
    • 5by6 – TwTS + UMP – Trichina worm
    • 1tmk - TS + TMP – yeast
    • 1tdc, 1thy, 2tdm, 5x5d – LcTS + UMP
    • 1tsv, 1tsx, 1tsy, 1njd, 1njb, 1vza, 1vzb, 1jmf, 1jmg, 1jmh, 1jmi, 1bo7, 1bo8, 1bp6, 1bpj, 1bp0, 2g86, 2g89, 2g8a, 2g8d - LcTS (mutant) + UMP
    • 1vzc - LcTS (mutant) + fluoro-UMP
    • 1nja, 1njc - LcTS (mutant) + CMP
    • 1nje - LcTS + CMP
    • 1tdb - LcTS + fluoro-UMP
    • 1tsl, 1tsm - LcTS + inhibitor
    • 4tmk, 5tmp - EcTS + inhibitor
    • 1an5 - EcTS + inhibitor
    • 1fwm - EcTS (mutant) + inhibitor
    • 1bid - EcTS + UMP
    • 1aob, 1bdu - EcTS + deoxyuridine derivative
    • 1f4c, 1f4e - EcTS + tosyl-proline derivative
    • 1f4d - EcTS (mutant) + tosyl-proline derivative
    • 1f4f, 1f4g - EcTS + glutamyl-proline derivative
    • 2vet - EcTS (mutant) + UMP
    • 3b9h - EcTS + nitro-UMP
    • 3bfi - EcTS (mutant) + nitro-UMP
    • 4dq1 - TS + UMP – Staphylococcus aureus
    • 3uwl – EfTS + 5-formyl tetrahydrofolate – Enterococcus faecalis
    • 6qya – EfTS + dUMP
    • 5j7w – EfTS + drug
    • 4foa - MtTS + fluoro-UMP – Mycobacterium tuberculosis
    • 4h0u – CgTS + UMP
    • 4xsc - VvTS + d-Uridine derivative
    • 4xsd - VvTS + dUMP
  • Thymidylate synthase ternary complex
    • 1hvy, 1i00, 5x5q, 5x66, 5x67 - hTS + drug + UMP
    • 1e2d, 1e2e, 1e2f - hTS (mutant) + ADP + TMP
    • 5hs3, 6pf6, 6pf5, 6pf4, 6pf3, 6ojv, 6oju - hTS + inhibitor + dUMP
    • 1ju6, 1juj - hTS (mutant) + inhibitor + UMP
    • 5fct - mTS + inhibitor + fluoro-UMP
    • [[4eb4 - mTS + drug + UMP
    • 6f6z - mTS + folate derivative + CMP derivative
    • 1rts, 2tsr - TS + drug + UMP – rat
    • 4iqq – nTS + UMP + drug
    • 5noo - TS + drug + UMP – Caenorhabditis elegans
    • 5m4z - TwTS + folate derivative + CMP derivative
    • 2tdd - LcTS + inhibitor+ fluoro-UMP
    • 1vzd - LcTS (mutant) + inhibitor+ fluoro-UMP
    • 1vze, 1tvu, 1tvv, 1tvw - LcTS (mutant) + inhibitor+ UMP
    • 1lca, 1lce, 3bnz - LcTS + inhibitor+ UMP
    • 1lcb - LcTS + inhibitor+ TMP
    • 3byx, 3bz0, 3c06, 3c0a, 3ijz, 3ik0, 3ik1 - LcTS + phthalimidic derivative + UMP
    • 1tys - EcTS + inhibitor+ TMP
    • 2fto, 3bgx - EcTS (mutant) + inhibitor+ TMP
    • 1tlc - EcTS + inhibitor+ GMP
    • 1syn, 1tsd - EcTS + inhibitor+ UMP
    • 2bbq, 2tsc, 1kce, 1trg, 1kzi, 4isk, 4lrr - EcTS + inhibitor+ UMP
    • 1zpr, 1aiq, 1dna, 1bq1, 1kzj, 2vf0, 3b5b - EcTS (mutant) + inhibitor+ UMP
    • 1tls, 1tsn - EcTS + inhibitor+ fluoro-UMP
    • 3bhl, 3bhr - EcTS + inhibitor+ nitro-UMP
    • 1bjg - EcTS (mutant) + inhibitor+ fluoro-UMP
    • 2kce, 1axw - EcTS + drug + UMP
    • 1jtq, 1jtu, 1jut, 1jg0, 2a9w - EcTS + inhibitor+ UMP
    • 1nce - EcTS (mutant) + inhibitor+ UMP
    • 1ddu, 1tdu - EcTS + deoxyuridine derivative + inhibitor
    • 6cdz - EcTS + deoxyuridine + UMP
    • 4gev - EcTS + deoxyuridine derivative + cofactor analog
    • 6nnr - EcTS + deoxyuridine derivative + folate derivative
    • 1b02 - BsTS + inhibitor+ fluoro-UMP
    • 1ci7 - PcTS + inhibitor+ UMP – Pneumocystis carinii
    • 1f28 - PcTS + inhibitor+ UMP
    • 2aaz - TS + inhibitor+ UMP – Filobasidiella neoformans
    • 3qj7 - MtTS + spermine + UMP
    • 4fog - MtTS + fluoro-UMP + methy-DHF
    • 4fox, 4fqs - MtTS + inhibitor + fluoro-UMP
    • 4o7u - EfTS + phthalimidic derivative + folate derivative
    • 6qxs - EfTS + fluoro-dUMP + folate derivative
  • Flavin-dependent thymidylate synthase ThyX
    • 2af6, 3gwc - MtTS + FAD + halo-UMP
    • 3hzg - MtTS + FAD
    • 2gq2 - MtTS (mutant) + NADP
    • 2cfa - TS + FAD – Paramecium bursaria chlorella virus
    • 5jfe - TmTS + FAD + UMP – Thermotoga maritima
    • 3g4a, 3g4c, 3n0b, 3n0c - TS (mutant) + FAD + UMP
    • 1o24 – TmTS
    • 1o25 – TmTS + UMP
    • 1o2a – TmTS + FAD
    • 4gtc, 4gtl, 4kar – TmTS (mutant) + FAD
    • 1o26 – TmTS + FAD + UMP
    • 4gtd, 4kas, 4kat, 5iot – TmTS (mutant) + FAD + UMP
    • 1o27, 1o28, 1o29 – TmTS + FAD + halo-UMP
    • 1o2b – TmTS + FAD + phosphate
    • 4gta – TmTS + FAD + UMP + folate derivative
    • 4gt9 – TmTS + FAD + UMP + folate
    • 4gtf – TmTS (mutant) + FAD + UMP + folate
    • 4gte – TmTS (mutant) + FAD + folate
    • 4gtb – TmTS + FAD + UMP + drug
    • 5chp – TmTS + FAD + UMP + inhibitor
    • 5ioq, 5ior – TmTS + FAD + d-Uridine derivative
    • 5ios, 2iot – TmTS (mutant) + FAD + dUMP
    • 3ge9 - CgTS
    • 3fnn - CgTS + FAD
    • 3ah5, 3n3y - TS + FAD + UMP – Helicobacter pylori
    • 4p5a, 4p5b – TS + FAD + dUMP derivative – Streptomyces cacaoi
    • 6j61 - TS + FAD – Thermus thermophilus

}}

References

  1. ↑ Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem. 1990 Nov 25;265(33):20277-84. PMID:2243092
  2. ↑ Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell. 2004 Apr;5(4):341-51. PMID:15093541
  3. ↑ Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan;9(1):69-75. PMID:9053905
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