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Thymidylate synthase 3D structures
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(New page: ==3D structures of thymidylate synthase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''Thymidylate synthase'...)
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Revision as of 09:38, 26 February 2020
3D structures of thymidylate synthase
Updated on 26-February-2020 {{#tree:id=OrganizedByTopic|openlevels=0|
- Thymidylate synthase
- 1hw3, 1hw4, 1hzw, 1ypv, 2onb, 4gyh, 4h1i, 4up1, 5x5a, 5x693n5g, 4kpw - hTS – human
- 2rd8, 2rda, 3egy, 3ehi, 3eaw, 3ebu, 3ed7, 3edw, 3ef9, 3ejl, 3gg5, 3gh0, 3gh2, 4jef, 4o1u, 4o1x, 5x4w, 5x4x, 5x4y, 6qyq – hTS (mutant)
- 3ihi, 6qyj – mTS – mouse
- 4iqb – nTS – nematode
- 3tms, 1tjs, 1f4b, 2ftq – EcTS – Escherichia coli
- 1ajm, 1bq2, 1qqq, 1ev5, 1ev8, 1evf, 1evg, 1ffl, 2g8x, 2ftn - EcTS (mutant)
- 4tms, 1tda - LcTS – Lactobacillus casei
- 1tsw, 1tsz - LcTS (mutant)
- 1tis – TS – Enterobacteria phage T4
- 1bsf, 1bko, 1bkp, 1bsp - BsTS - Bacillus subtilis
- 3ix6 – BmTS – Brucella melitensis
- 3kgb – TS – Encephalitozoon cuniculi
- 3v8h – TS – Burkholderia thailandensis
- 4h0r - CgTS – Corynebacterium glutamicum
- 4xse - VvTS – Varicella-zoster virus
- 6auj - TS – Elizabethkingia anophelis
- 1hw3, 1hw4, 1hzw, 1ypv, 2onb, 4gyh, 4h1i, 4up1, 5x5a, 5x693n5g, 4kpw - hTS – human
- Thymidylate synthase binary complex
- 6qsh - hTS + dUMP
- 3hb8 - hTS (mutant) + UMP
- 6qxg - hTS + fluoro-dUMP
- 3h9k - hTS (mutant) + fluoro-dUMP
- 5wrn - hTS + CMP
- 3ob7 - hTS (mutant) + glutathione
- 4g2o – hTS (mutant) + purpurogallin
- 4gd7 – hTS + purpurogallin
- 4g6w – hTS (mutant) + bromobenzine-triol
- 3n5e, 4fgt - hTS + peptide inhibitor
- 4e28 - hTS + inhibitor
- 6r2e – hTS (mutant) + folate derivative
- 4e5o - mTS + UMP
- 4ein – mTS + substrate analog
- 4ez8 – mTS + substrate analog + dihydrofolate
- 4psg – nTS + inhibitor
- 4irr, 4isw – nTS + UMP
- 5by6 – TwTS + UMP – Trichina worm
- 1tmk - TS + TMP – yeast
- 1tdc, 1thy, 2tdm, 5x5d – LcTS + UMP
- 1tsv, 1tsx, 1tsy, 1njd, 1njb, 1vza, 1vzb, 1jmf, 1jmg, 1jmh, 1jmi, 1bo7, 1bo8, 1bp6, 1bpj, 1bp0, 2g86, 2g89, 2g8a, 2g8d - LcTS (mutant) + UMP
- 1vzc - LcTS (mutant) + fluoro-UMP
- 1nja, 1njc - LcTS (mutant) + CMP
- 1nje - LcTS + CMP
- 1tdb - LcTS + fluoro-UMP
- 1tsl, 1tsm - LcTS + inhibitor
- 4tmk, 5tmp - EcTS + inhibitor
- 1an5 - EcTS + inhibitor
- 1fwm - EcTS (mutant) + inhibitor
- 1bid - EcTS + UMP
- 1aob, 1bdu - EcTS + deoxyuridine derivative
- 1f4c, 1f4e - EcTS + tosyl-proline derivative
- 1f4d - EcTS (mutant) + tosyl-proline derivative
- 1f4f, 1f4g - EcTS + glutamyl-proline derivative
- 2vet - EcTS (mutant) + UMP
- 3b9h - EcTS + nitro-UMP
- 3bfi - EcTS (mutant) + nitro-UMP
- 4dq1 - TS + UMP – Staphylococcus aureus
- 3uwl – EfTS + 5-formyl tetrahydrofolate – Enterococcus faecalis
- 6qya – EfTS + dUMP
- 5j7w – EfTS + drug
- 4foa - MtTS + fluoro-UMP – Mycobacterium tuberculosis
- 4h0u – CgTS + UMP
- 4xsc - VvTS + d-Uridine derivative
- 4xsd - VvTS + dUMP
- 6qsh - hTS + dUMP
- Thymidylate synthase ternary complex
- 1hvy, 1i00, 5x5q, 5x66, 5x67 - hTS + drug + UMP
- 1e2d, 1e2e, 1e2f - hTS (mutant) + ADP + TMP
- 5hs3, 6pf6, 6pf5, 6pf4, 6pf3, 6ojv, 6oju - hTS + inhibitor + dUMP
- 1ju6, 1juj - hTS (mutant) + inhibitor + UMP
- 5fct - mTS + inhibitor + fluoro-UMP
- [[4eb4 - mTS + drug + UMP
- 6f6z - mTS + folate derivative + CMP derivative
- 1rts, 2tsr - TS + drug + UMP – rat
- 4iqq – nTS + UMP + drug
- 5noo - TS + drug + UMP – Caenorhabditis elegans
- 5m4z - TwTS + folate derivative + CMP derivative
- 2tdd - LcTS + inhibitor+ fluoro-UMP
- 1vzd - LcTS (mutant) + inhibitor+ fluoro-UMP
- 1vze, 1tvu, 1tvv, 1tvw - LcTS (mutant) + inhibitor+ UMP
- 1lca, 1lce, 3bnz - LcTS + inhibitor+ UMP
- 1lcb - LcTS + inhibitor+ TMP
- 3byx, 3bz0, 3c06, 3c0a, 3ijz, 3ik0, 3ik1 - LcTS + phthalimidic derivative + UMP
- 1tys - EcTS + inhibitor+ TMP
- 2fto, 3bgx - EcTS (mutant) + inhibitor+ TMP
- 1tlc - EcTS + inhibitor+ GMP
- 1syn, 1tsd - EcTS + inhibitor+ UMP
- 2bbq, 2tsc, 1kce, 1trg, 1kzi, 4isk, 4lrr - EcTS + inhibitor+ UMP
- 1zpr, 1aiq, 1dna, 1bq1, 1kzj, 2vf0, 3b5b - EcTS (mutant) + inhibitor+ UMP
- 1tls, 1tsn - EcTS + inhibitor+ fluoro-UMP
- 3bhl, 3bhr - EcTS + inhibitor+ nitro-UMP
- 1bjg - EcTS (mutant) + inhibitor+ fluoro-UMP
- 2kce, 1axw - EcTS + drug + UMP
- 1jtq, 1jtu, 1jut, 1jg0, 2a9w - EcTS + inhibitor+ UMP
- 1nce - EcTS (mutant) + inhibitor+ UMP
- 1ddu, 1tdu - EcTS + deoxyuridine derivative + inhibitor
- 6cdz - EcTS + deoxyuridine + UMP
- 4gev - EcTS + deoxyuridine derivative + cofactor analog
- 6nnr - EcTS + deoxyuridine derivative + folate derivative
- 1b02 - BsTS + inhibitor+ fluoro-UMP
- 1ci7 - PcTS + inhibitor+ UMP – Pneumocystis carinii
- 1f28 - PcTS + inhibitor+ UMP
- 2aaz - TS + inhibitor+ UMP – Filobasidiella neoformans
- 3qj7 - MtTS + spermine + UMP
- 4fog - MtTS + fluoro-UMP + methy-DHF
- 4fox, 4fqs - MtTS + inhibitor + fluoro-UMP
- 4o7u - EfTS + phthalimidic derivative + folate derivative
- 6qxs - EfTS + fluoro-dUMP + folate derivative
- 1hvy, 1i00, 5x5q, 5x66, 5x67 - hTS + drug + UMP
- Bifunctional dihydrofolate reductase-thymidylate synthase see Dihydrofolate reductase
- Flavin-dependent thymidylate synthase ThyX
- 2af6, 3gwc - MtTS + FAD + halo-UMP
- 3hzg - MtTS + FAD
- 2gq2 - MtTS (mutant) + NADP
- 2cfa - TS + FAD – Paramecium bursaria chlorella virus
- 5jfe - TmTS + FAD + UMP – Thermotoga maritima
- 3g4a, 3g4c, 3n0b, 3n0c - TS (mutant) + FAD + UMP
- 1o24 – TmTS
- 1o25 – TmTS + UMP
- 1o2a – TmTS + FAD
- 4gtc, 4gtl, 4kar – TmTS (mutant) + FAD
- 1o26 – TmTS + FAD + UMP
- 4gtd, 4kas, 4kat, 5iot – TmTS (mutant) + FAD + UMP
- 1o27, 1o28, 1o29 – TmTS + FAD + halo-UMP
- 1o2b – TmTS + FAD + phosphate
- 4gta – TmTS + FAD + UMP + folate derivative
- 4gt9 – TmTS + FAD + UMP + folate
- 4gtf – TmTS (mutant) + FAD + UMP + folate
- 4gte – TmTS (mutant) + FAD + folate
- 4gtb – TmTS + FAD + UMP + drug
- 5chp – TmTS + FAD + UMP + inhibitor
- 5ioq, 5ior – TmTS + FAD + d-Uridine derivative
- 5ios, 2iot – TmTS (mutant) + FAD + dUMP
- 3ge9 - CgTS
- 3fnn - CgTS + FAD
- 3ah5, 3n3y - TS + FAD + UMP – Helicobacter pylori
- 4p5a, 4p5b – TS + FAD + dUMP derivative – Streptomyces cacaoi
- 6j61 - TS + FAD – Thermus thermophilus
- 2af6, 3gwc - MtTS + FAD + halo-UMP
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