Johnson's Monday Lab Sandbox for Insulin Receptor
From Proteopedia
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===How Insulin Binds=== | ===How Insulin Binds=== | ||
| - | The insulin receptor unit has four separate sites for the insulin molecule to bind to. There are two pairs of two identical binding sites referred to as 1 and 1' and then 2 and 2'. The insulin molecules bind to these sites mostly through hydrophobic interactions. Despite a majority of the interactions being similar, sites 1 and 1' have a higher binding affinity than sites 2 and 2' due to site one having a larger surface area (706 square angstroms) exposed for insulin to bind to compared to site 2 (394 square angstroms)<ref name="Uchikawa" | + | The insulin receptor unit has four separate sites for the insulin molecule to bind to. There are two pairs of two identical binding sites referred to as 1 and 1' and then 2 and 2'. The insulin molecules bind to these sites mostly through hydrophobic interactions. Despite a majority of the interactions being similar, sites 1 and 1' have a higher binding affinity than sites 2 and 2' due to site one having a larger surface area (706 square angstroms) exposed for insulin to bind to compared to site 2 (394 square angstroms)<ref name="Uchikawa"> |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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| + | <ref name="Uchikawa">DOI:10.7554/eLife.48630<ref/> | ||
<references/> | <references/> | ||
Revision as of 18:08, 20 March 2020
Your Heading Here (maybe something like 'Structure')
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