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Johnson's Monday Lab Sandbox for Insulin Receptor

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===How Insulin Binds===
===How Insulin Binds===
[http://en.wikipedia.org/wiki/Hydrophobic_effect hydrophic interactions]
[http://en.wikipedia.org/wiki/Hydrophobic_effect hydrophic interactions]
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[http://</StructureSection>
[http://</StructureSection>

Revision as of 22:58, 21 March 2020

Your Heading Here (maybe something like 'Structure')

Insulin Receptor with Four Insulin Bound - 6sof

Drag the structure with the mouse to rotate

References

[3] [4] [5]


  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Uchikawa E, Choi E, Shang G, Yu H, Bai XC. Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife. 2019 Aug 22;8. pii: 48630. doi: 10.7554/eLife.48630. PMID:31436533 doi:http://dx.doi.org/10.7554/eLife.48630
  4. ↑ Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: 6/1/a009191. doi:, 10.1101/cshperspect.a009191. PMID:24384568 doi:http://dx.doi.org/10.1101/cshperspect.a009191
  5. ↑ De Meyts P. The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia. 1994 Sep;37 Suppl 2:S135-48. doi: 10.1007/bf00400837. PMID:7821729 doi:http://dx.doi.org/10.1007/bf00400837

Student Contributors

  • Maxwell Todd
  • Abby Hillan
  • Andrew Scheel

Proteopedia Page Contributors and Editors (what is this?)

Maxwell Todd, Abigail Hillan, Andrew Scheel

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