Virus protease

From Proteopedia

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Line 84: Line 84:
**[[2o8m]] – HCVP (mutant)<br />
**[[2o8m]] – HCVP (mutant)<br />
**[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br />
**[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br />
 +
**[[6nzt]], [[6nzv]] – HCVP (mutant) + inhibitor<br />
*'''Orf 17'''
*'''Orf 17'''
Line 95: Line 96:
**[[2fom]] - DvNs2b/DvNs3<br />
**[[2fom]] - DvNs2b/DvNs3<br />
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
 +
**[[6mo0]], [[6mo1]], [[6mo2]] - DvNs2b residues 1394-1440 + inhibitor<br />
**[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
**[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
**[[2jlq]] – DvNs3 residues 1646-2092 <br />
**[[2jlq]] – DvNs3 residues 1646-2092 <br />
Line 125: Line 127:
**[[4b08]] – YAV + inhibitor<br />
**[[4b08]] – YAV + inhibitor<br />
**[[4izj]], [[4izk]] – YAV Vp4 (mutant)
**[[4izj]], [[4izk]] – YAV Vp4 (mutant)
 +
 +
*'''Yellow fever virus protease'''
 +
 +
**[[6urv]] – NS2B + NS3 <br />
 +
 +
*'''Zika virus protease'''
 +
 +
**[[6um3]] – NS2B + NS3 <br />
*'''Pseudorabies virus protease'''
*'''Pseudorabies virus protease'''
Line 175: Line 185:
**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus <br />
**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus <br />
**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor <br />
**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor <br />
 +
 +
*'''SARS COV-19 protease'''
 +
 +
**[[6lu7]] – COV-19 + inhibitor <br />
 +
 +
*'''Murine coronavirus protease'''
 +
 +
**[[6jij]] – MCP + peptide inhibitor <br />
*'''Coronavirus HKU4 protease'''
*'''Coronavirus HKU4 protease'''
Line 207: Line 225:
**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
**[[3e90]] - WNVP + inhibitor<br />
**[[3e90]] - WNVP + inhibitor<br />
 +
 +
*'''African swine fever virus protease'''
 +
 +
**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
}}
}}

Revision as of 08:36, 27 March 2020

Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq)

Drag the structure with the mouse to rotate

3D Structures of Virus proteases

Updated on 27-March-2020

References

  1. ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
  2. ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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