Virus protease
From Proteopedia
(Difference between revisions)
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*[[Molecular Playground/Dengue Virus Protease]]<br /> | *[[Molecular Playground/Dengue Virus Protease]]<br /> | ||
*[[FMDV 3C]] for Foot-and-Mouth virus protease | *[[FMDV 3C]] for Foot-and-Mouth virus protease | ||
| + | == 3D Structures of Virus proteases == | ||
| + | [[Virus proteases 3D strutures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[2o8m]] – HCVP (mutant)<br /> | **[[2o8m]] – HCVP (mutant)<br /> | ||
**[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br /> | **[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br /> | ||
| - | **[[6nzt]], [[6nzv]] – HCVP (mutant) + inhibitor<br /> | + | **[[6nzt]], [[6nzv]], [[6piu]], [[6piv]], [[6piw]], [[6pix]], [[6piy]], [[6piz]], [[6pj0]], [[6pj1]], [[6pj2]] – HCVP (mutant) + inhibitor<br /> |
*'''Orf 17''' | *'''Orf 17''' | ||
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**[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br /> | **[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br /> | ||
**[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br /> | **[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br /> | ||
| + | **[[6izy]] – DvNs5 RNA polymerase domain residues 2742-3387 <br /> | ||
| + | **[[6izx]] – DvNs5 RNA polymerase domain residues 2742-3387 + inhibitor<br /> | ||
*'''Herpes simplex virus protease''' | *'''Herpes simplex virus protease''' | ||
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*'''Zika virus protease''' | *'''Zika virus protease''' | ||
| - | **[[6um3]] – NS2B + NS3 <br /> | + | **[[6um3]], [[6jpw]] – NS2B + NS3 <br /> |
*'''Pseudorabies virus protease''' | *'''Pseudorabies virus protease''' | ||
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*'''Porcine epidemic diarrhea virus protease''' | *'''Porcine epidemic diarrhea virus protease''' | ||
| - | **[[5hyo]] – PEDVP – porcine epidemic diarrhea virus <br /> | + | **[[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br /> |
*'''Coronavirus protease''' | *'''Coronavirus protease''' | ||
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*'''SARS COV-19 protease''' | *'''SARS COV-19 protease''' | ||
| + | **[[6y84]] – COV-19 <br /> | ||
**[[6lu7]] – COV-19 + inhibitor <br /> | **[[6lu7]] – COV-19 + inhibitor <br /> | ||
Revision as of 09:37, 27 March 2020
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3D Structures of Virus proteases
Updated on 27-March-2020
References
- ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
- ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114
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