Sandbox 30004

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

Function

Host translation inhibitor nsp1. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.^[1][2]

Disease

Relevance

Structural highlights

Possible ATP binding site (residues 71, 73, 86, 106-108 in magenta