User:Bruna Oliveira de Almeida/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Introduction == | == Introduction == | ||
| - | The RNA dependent RNA polymerase (RdRp) of SARS-CoV-2 (also known as nsp12), which is responsible for a major outbreak of the disease called [[Coronavirus Disease 2019 (COVID-19)]], declared pandemic by WHO in 11 march 2020 <ref name="WHO">WHO. COVID-19 situation reports [Internet]. [cited 2020 May 15]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports </ref> is an enzyme that catalyzes the synthesis of RNA of the virus SARS-CoV-2 <ref name="structure"> PMID: 32277040 </ref>(2). This virus belongs to the betacoronavirus genus <ref name="pneumonia">PMID: 32015507</ref>(Zhou et al. 2020) and has a single stranded positive-sense RNA genome. Therefore, RNA dependent RNA polymerase plays a central role in the virus replication and livecycle. It’s also has been considered a good target for antiviral drugs <ref name="structure" /ref>(2). | + | The RNA dependent RNA polymerase (RdRp) of SARS-CoV-2 (also known as nsp12), which is responsible for a major outbreak of the disease called [[Coronavirus Disease 2019 (COVID-19)]], declared pandemic by WHO in 11 march 2020 <ref name="WHO">WHO. COVID-19 situation reports [Internet]. [cited 2020 May 15]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports </ref> is an enzyme that catalyzes the synthesis of RNA of the virus SARS-CoV-2 <ref name="structure"> PMID: 32277040 </ref>(2). This virus belongs to the betacoronavirus genus <ref name="pneumonia">PMID: 32015507</ref>(Zhou et al. 2020) and has a single stranded positive-sense RNA genome. Therefore, RNA dependent RNA polymerase plays a central role in the virus replication and livecycle. It’s also has been considered a good target for antiviral drugs <ref name="structure"/ref>(2). |
Revision as of 00:40, 14 June 2020
SARS-CoV-2 RNA-dependent RNA polymerase
| |||||||||||
