User:Milena Ortiz Ribeiro/Sandbox 1

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== Function ==
== Function ==
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TFAM is involved in many cellular functions including mtDNA transcription, maintenance, repair, and replication and its activity is vital in
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the maintenance of mtDNA copy number.<ref>PMID:25648146 </ref>
<ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref>
<ref>TONOLLI, P.N. <i> O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas.</i> São Paulo. 2013. </ref>

Revision as of 19:26, 15 June 2020

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References

  1. ↑ Zhang F, Qi Y, Zhou K, Zhang G, Linask K, Xu H. The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM. EMBO Rep. 2015 Apr;16(4):520-7. doi: 10.15252/embr.201439636. Epub 2015 Feb 3. PMID:25648146 doi:http://dx.doi.org/10.15252/embr.201439636
  2. ↑ TONOLLI, P.N. O papel do fator de transcrição mitocondrial A na proteção do DNA mitocondrial contra lesões oxidadas. São Paulo. 2013.
  3. ↑ Liu Y, Jin M, Wang Y, Zhu J, Tan R, Zhao J, Ji X, Jin C, Jia Y, Ren T, Xing J. MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. Signal Transduct Target Ther. 2020 May 5;5(1):59. doi: 10.1038/s41392-020-0155-5. PMID:32371956 doi:http://dx.doi.org/10.1038/s41392-020-0155-5
  4. ↑ Kozhukhar N, Alexeyev MF. Limited predictive value of TFAM in mitochondrial biogenesis. Mitochondrion. 2019 Nov;49:156-165. doi: 10.1016/j.mito.2019.08.001. Epub 2019, Aug 13. PMID:31419493 doi:http://dx.doi.org/10.1016/j.mito.2019.08.001
  5. ↑ Araujo LF, Siena ADD, Placa JR, Brotto DB, Barros II, Muys BR, Biagi CAO Jr, Peronni KC, Sousa JF, Molfetta GA, West LC, West AP, Leopoldino AM, Espreafico EM, Silva WA Jr. Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. Sci Rep. 2018 Sep 21;8(1):14190. doi: 10.1038/s41598-018-31170-6. PMID:30242167 doi:http://dx.doi.org/10.1038/s41598-018-31170-6
  6. ↑ Stiles AR, Simon MT, Stover A, Eftekharian S, Khanlou N, Wang HL, Magaki S, Lee H, Partynski K, Dorrani N, Chang R, Martinez-Agosto JA, Abdenur JE. Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. Mol Genet Metab. 2016 Sep;119(1-2):91-9. doi: 10.1016/j.ymgme.2016.07.001. Epub, 2016 Jul 4. PMID:27448789 doi:http://dx.doi.org/10.1016/j.ymgme.2016.07.001

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Milena Ortiz Ribeiro

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