6xxw

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==Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.==
==Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.==
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<StructureSection load='6xxw' size='340' side='right'caption='[[6xxw]]' scene=''>
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<StructureSection load='6xxw' size='340' side='right'caption='[[6xxw]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dict6 Dict6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxw OCA], [http://pdbe.org/6xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxw RCSB], [http://www.ebi.ac.uk/pdbsum/6xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxw ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DICTH_1429 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=309799 DICT6])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxw OCA], [http://pdbe.org/6xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxw RCSB], [http://www.ebi.ac.uk/pdbsum/6xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxw ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The beta-d-glucuronidase DtGlcA from Dictyoglomus thermophilum was engineered to generate an active thioglycoligase that is able to catalyse the formation of numerous S-glucuronides. Its X-ray structure analysis indicated the ability of the biocatalyst to bind aromatic thiol acceptors for S-glycosylation. Noteworthily, the DtGlcA mutant was found to be the first thioligase that is able to use a natural sugar donor different from the widely used synthetic para-nitrophenyl glycosides.
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Thioglycoligation of aromatic thiols using a natural glucuronide donor.,Kurdziel M, Kopec M, Paris A, Lewinski K, Lafite P, Daniellou R Org Biomol Chem. 2020 Jul 16. doi: 10.1039/d0ob00226g. PMID:32671369<ref>PMID:32671369</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6xxw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-glucuronidase]]
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[[Category: Dict6]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Daniellou R]]
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[[Category: Daniellou, R]]
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[[Category: Lafite P]]
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[[Category: Lafite, P]]
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[[Category: Glucuronide]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]

Revision as of 06:00, 5 August 2020

Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.

PDB ID 6xxw

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