7a0c
From Proteopedia
(Difference between revisions)
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==X-ray structure of NikA from Escherichia coli in complex with Fe-6-Me2-BPMCN== | ==X-ray structure of NikA from Escherichia coli in complex with Fe-6-Me2-BPMCN== | ||
| - | <StructureSection load='7a0c' size='340' side='right'caption='[[7a0c]]' scene=''> | + | <StructureSection load='7a0c' size='340' side='right'caption='[[7a0c]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A0C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7A0C FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7a0c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A0C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7A0C FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7a0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a0c OCA], [http://pdbe.org/7a0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7a0c RCSB], [http://www.ebi.ac.uk/pdbsum/7a0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7a0c ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QTT:2-[[(1~{S},2~{S})-2-[methyl-[(6-methylpyridin-2-yl)methyl]amino]cyclohexyl]-[(6-methylpyridin-2-yl)methyl]amino]ethanoic+acid'>QTT</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nikA, b3476, JW3441 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7a0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a0c OCA], [http://pdbe.org/7a0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7a0c RCSB], [http://www.ebi.ac.uk/pdbsum/7a0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7a0c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NIKA_ECOLI NIKA_ECOLI]] Involved in a nickel transport system, probably represents the nickel binder. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Performing a heterogeneous catalysis with proteins is still a challenge. Here, we demonstrate the importance of cross-linked crystals for sulfoxide oxidation by an artificial enzyme. The biohybrid consists of the insertion of an iron complex into a NikA protein crystal. The heterogeneous catalysts displays a better efficiency-with higher reaction kinetics, a better stability and expand the substrate scope compared to its solution counterpart. Designing crystalline artificial enzymes represents a good alternative to soluble or supported enzymes for the future of synthetic biology. | ||
| + | |||
| + | A Selective Sulfide Oxidation catalyzed by Heterogeneous Artificial Enzymes Iron@NikA.,Menage S, Lopez S, Marchi-Delapierre C, Cavazza C Chemistry. 2020 Oct 20. doi: 10.1002/chem.202003746. PMID:33079395<ref>PMID:33079395</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7a0c" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ecoli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cavazza C]] | + | [[Category: Cavazza, C]] |
| - | [[Category: Menage S]] | + | [[Category: Menage, S]] |
| + | [[Category: Artificial metalloenzyme]] | ||
| + | [[Category: Cross-linked enzyme crystal]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Sulfoxidation]] | ||
Revision as of 07:15, 25 November 2020
X-ray structure of NikA from Escherichia coli in complex with Fe-6-Me2-BPMCN
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