Sandbox Reserved 1654
From Proteopedia
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==Cytplasmic Polyadenylation Element-binding Protein (CPEB)== | ==Cytplasmic Polyadenylation Element-binding Protein (CPEB)== | ||
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Structure == | == Structure == | ||
All CPEB proteins have a similar structure : | All CPEB proteins have a similar structure : | ||
| - | + | A C-terminal region composed of : 2 recognition patterns (RRMs) which allow a good positioning of RNA and a high fidelity, they are essential for the CPE specific recognition ; 2 zinc finger patterns containing a specific RNA-binding protein sequence, which play a role in affinity but not in specificity. | |
| - | + | A N-terminal region, which is a regulatory region with phosphorylation and dephospho rylation sites. This region is variable in length and composition. | |
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| + | <StructureSection load='2m13' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
Revision as of 17:52, 3 January 2021
| This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664. |
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Cytplasmic Polyadenylation Element-binding Protein (CPEB)
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Structure
All CPEB proteins have a similar structure : A C-terminal region composed of : 2 recognition patterns (RRMs) which allow a good positioning of RNA and a high fidelity, they are essential for the CPE specific recognition ; 2 zinc finger patterns containing a specific RNA-binding protein sequence, which play a role in affinity but not in specificity. A N-terminal region, which is a regulatory region with phosphorylation and dephospho rylation sites. This region is variable in length and composition.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
