Sandbox Reserved 1658
From Proteopedia
(Difference between revisions)
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<p align="justify">Neuropilin is a transmembrane protein which has been highly conserved through evolution. Two different types of Neuropilin have been discovered in vertebrates: Neuropilin 1 (NRP1) and Neuropilin 2 (NRP2). They have 44% of similarity by comparing their amino acid sequences. In the human genome, it is located on the chromosome 10 and their molar weights flucatuate between 120 and 130 kDa. | <p align="justify">Neuropilin is a transmembrane protein which has been highly conserved through evolution. Two different types of Neuropilin have been discovered in vertebrates: Neuropilin 1 (NRP1) and Neuropilin 2 (NRP2). They have 44% of similarity by comparing their amino acid sequences. In the human genome, it is located on the chromosome 10 and their molar weights flucatuate between 120 and 130 kDa. | ||
These proteins are particularly found in the membrane of the endothelial cells but the Neuropilin 1 is involved in several process such as axon guidance during the embryonic development, recognition of the Vascular Endothelial cell Growth Factor ([[VEGF]]) and recognition of covid-19.</p> | These proteins are particularly found in the membrane of the endothelial cells but the Neuropilin 1 is involved in several process such as axon guidance during the embryonic development, recognition of the Vascular Endothelial cell Growth Factor ([[VEGF]]) and recognition of covid-19.</p> | ||
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| + | == Structural highlights == | ||
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| + | <p align="justify">The Neuropilin 1 has three different domains. A cytoplasmic domain which contains 40 residues, a transmembrane domain which contains 24 residues and a 850 residues ectodomain. The latter is an assembly of five individual motifs (a1,a2,b1,b2 and c). It contains, hence two CUB domains (a1/a2), two homologous domains to coagulation factors V/VIII (b1/b2) and a MAM domain (c). The ligand binding is mediated by the (a1/a2) and (b1/b2) portion of the ectodomain while the c domain mediates Neuripilin oligomerization. | ||
| + | <scene name='86/868191/B1_beta_barell/1'>B1 is a beta barell</scene>. | ||
| + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.</p> | ||
== Function == | == Function == | ||
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== Role in covid contamination == | == Role in covid contamination == | ||
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| - | == Structural highlights == | ||
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| - | <p align="justify">The Neuropilin 1 has three different domains. A cytoplasmic domain which contains 40 residues, a transmembrane domain which contains 24 residues and a 850 residues ectodomain. The latter is an assembly of five individual motifs (a1,a2,b1,b2 and c). It contains, hence two CUB domains (a1/a2), two homologous domains to coagulation factors V/VIII (b1/b2) and a MAM domain (c). The ligand binding is mediated by the (a1/a2) and (b1/b2) portion of the ectodomain while the c domain mediates Neuripilin oligomerization. | ||
| - | <scene name='86/868191/B1_beta_barell/1'>B1 is a beta barell</scene>. | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.</p> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:18, 9 January 2021
| This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664. |
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