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== Relevance ==
== Relevance ==
-
Even if a lot is already known about Piezo1's structure, the precise mechanism of the pore is still unknown. Moreover, Piezo1 is present in a large number of tissues, but the differences in its roles are unclear. More researches carried out regarding these two points would allow a better understanding of diseases liked to Piezo1 (like DHS), and thus a better treatment of those diseases.
+
Even if a lot is already known about Piezo1's structure, the precise mechanism of the pore is still unknown. Moreover, Piezo1 is present in a large number of tissues, but the differences in its roles are unclear. More researches carried out regarding these two points would allow a better understanding of diseases linked to Piezo1 (like DHS), and thus a better treatment of those diseases.
== Structural highlights ==
== Structural highlights ==

Revision as of 09:43, 10 January 2021

Piezo 1

Drag the structure with the mouse to rotate

References

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  2. 2.0 2.1 Parpaite T, Coste B. Piezo channels. Curr Biol. 2017 Apr 3;27(7):R250-R252. doi: 10.1016/j.cub.2017.01.048. PMID:28376327 doi:http://dx.doi.org/10.1016/j.cub.2017.01.048
  3. 3.0 3.1 3.2 3.3 Wei L, Mousawi F, Li D, Roger S, Li J, Yang X, Jiang LH. Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation. Front Pharmacol. 2019 Nov 6;10:1304. doi: 10.3389/fphar.2019.01304. eCollection, 2019. PMID:31780935 doi:http://dx.doi.org/10.3389/fphar.2019.01304
  4. Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Force-induced conformational changes in PIEZO1. Nature. 2019 Sep;573(7773):230-234. doi: 10.1038/s41586-019-1499-2. Epub 2019 Aug, 21. PMID:31435018 doi:http://dx.doi.org/10.1038/s41586-019-1499-2
  5. Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad KR, Evans PC, Ainscough JF, Beech DJ. Piezo1 integration of vascular architecture with physiological force. Nature. 2014 Nov 13;515(7526):279-82. doi: 10.1038/nature13701. Epub 2014 Aug 10. PMID:25119035 doi:http://dx.doi.org/10.1038/nature13701
  6. 6.0 6.1 6.2 6.3 Liang X, Howard J. Structural Biology: Piezo Senses Tension through Curvature. Curr Biol. 2018 Apr 23;28(8):R357-R359. doi: 10.1016/j.cub.2018.02.078. PMID:29689211 doi:http://dx.doi.org/10.1016/j.cub.2018.02.078
  7. Guo YR, MacKinnon R. Structure-based membrane dome mechanism for Piezo mechanosensitivity. Elife. 2017 Dec 12;6. pii: 33660. doi: 10.7554/eLife.33660. PMID:29231809 doi:http://dx.doi.org/10.7554/eLife.33660
  8. Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Force-induced conformational changes in PIEZO1. Nature. 2019 Sep;573(7773):230-234. doi: 10.1038/s41586-019-1499-2. Epub 2019 Aug, 21. PMID:31435018 doi:http://dx.doi.org/10.1038/s41586-019-1499-2
  9. 9.0 9.1 Zhou, Z. (2019). Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases. 139–155. DOI 10.4236/jbm.2019.712012
  10. Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J, Li X, Xiao B. Structure and mechanogating mechanism of the Piezo1 channel. Nature. 2018 Feb 22;554(7693):487-492. doi: 10.1038/nature25743. Epub 2018 Jan, 22. PMID:29469092 doi:http://dx.doi.org/10.1038/nature25743
  11. Guo YR, MacKinnon R. Structure-based membrane dome mechanism for Piezo mechanosensitivity. Elife. 2017 Dec 12;6. pii: 33660. doi: 10.7554/eLife.33660. PMID:29231809 doi:http://dx.doi.org/10.7554/eLife.33660
  12. Ge J, Li W, Zhao Q, Li N, Chen M, Zhi P, Li R, Gao N, Xiao B, Yang M. Architecture of the mammalian mechanosensitive Piezo1 channel. Nature. 2015 Nov 5;527(7576):64-9. doi: 10.1038/nature15247. Epub 2015 Sep 21. PMID:26390154 doi:http://dx.doi.org/10.1038/nature15247
  13. 13.0 13.1 Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB. Structure of the mechanically activated ion channel Piezo1. Nature. 2017 Dec 20. pii: nature25453. doi: 10.1038/nature25453. PMID:29261642 doi:http://dx.doi.org/10.1038/nature25453
  14. 14.0 14.1 Ge J, Li W, Zhao Q, Li N, Chen M, Zhi P, Li R, Gao N, Xiao B, Yang M. Architecture of the mammalian mechanosensitive Piezo1 channel. Nature. 2015 Nov 5;527(7576):64-9. doi: 10.1038/nature15247. Epub 2015 Sep 21. PMID:26390154 doi:http://dx.doi.org/10.1038/nature15247
  15. 15.0 15.1 15.2 15.3 Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J, Li X, Xiao B. Structure and mechanogating mechanism of the Piezo1 channel. Nature. 2018 Feb 22;554(7693):487-492. doi: 10.1038/nature25743. Epub 2018 Jan, 22. PMID:29469092 doi:http://dx.doi.org/10.1038/nature25743
  16. doi: https://dx.doi.org/10.4236/jbm.2019.712012
  17. 17.0 17.1 Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Feneant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garcon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A. Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nat Commun. 2013;4:1884. doi: 10.1038/ncomms2899. PMID:23695678 doi:http://dx.doi.org/10.1038/ncomms2899
  18. Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 9;121(19):3925-35, S1-12. doi: 10.1182/blood-2013-02-482489. Epub, 2013 Mar 11. PMID:23479567 doi:http://dx.doi.org/10.1182/blood-2013-02-482489
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