Virus coat protein

Virus coat proteins (VCP) or capsid proteins coat the virus^[1]. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. The outer capsid protein VP4 is a virus spike-forming protein which mediates the virial attachment to the host epithelial cell receptors. The distal portion of Vp4 - Vp8* - is implicated in binding the cellular receptor^[2]. VP4 is an outer capsid protein of non-enveloped viruses. VP4 attaches to sialic acid or to integrin heterodimers^[3]. VP4 domains include: VP5* which forms the foot of the spike and acts in the permeabilization of the cell membrane and VP8* which forms the head of the spike and binds to sialic acid.

The biological assembly of HIV-I coat protein is (PDB entry 3gv2).

• Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates
• Canine parvovirus
• SV40 Capsid Simplified
• Structure of the Ebola virus nucleoprotein - RNA complex
• Zika virus capsid protein
• Tobacco Mosaic Virus
• Human rhinovirus
• Hiv-1 gag
• Adeno-associated virus 9 Vp1 see Adeno-Associated Virus.

See also Viral capsids

3D structures of virus coat proteins

Virus coat proteins 3D structures