Virus protease

From Proteopedia

Revision as of 11:17, 24 January 2021

spinqualitylabelsall models Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of Virus protease Function Virus protease or 3C protease or virus proteinase are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.[1] F Disease Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis. Structural highlights Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The (PDB entry 1cqq).[2] . See also Immunodeficiency virus protease Human Immunodeficiency Virus HIV-1 protease HIV Protease Inhibitor Pharmacokinetics HIV Protease Inhibitor Resistance Profile HIV Protease Resistance Molecular Playground/Dengue Virus Protease Viability of a drug-resistant HIV-1 protease mutant FMDV 3C for Foot-and-Mouth virus protease SARS Coronavirus Main Proteinase 3D Structures of Virus protease Virus protease 3D structures

References

1. ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
2. ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114