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Aminotransferase 3D structures

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Line 24: Line 24:
**[[1oat]] – hOA + PLP – human <br />
**[[1oat]] – hOA + PLP – human <br />
-
**[[1gbn]], [[2can]] – hOA + PLP + inhibitor <br />
+
**[[1gbn]], [[2can]], [[5vwo]], [[6oia]], [[6v8c]], [[6v8d]] – hOA + PLP + inhibitor <br />
**[[2oat]] – hOA + PLP derivative <br />
**[[2oat]] – hOA + PLP derivative <br />
**[[2byj]], [[2byl]] – hOA (mutant) + PLP <br />
**[[2byj]], [[2byl]] – hOA (mutant) + PLP <br />
 +
**[[7jx9]] – hOA + intermediate + inhibitor <br />
**[[5eav]] – TgOA – ''Toxoplasma gondii'' <br />
**[[5eav]] – TgOA – ''Toxoplasma gondii'' <br />
**[[5eqc]], [[4zwm]] – TgOA + PLP <br />
**[[5eqc]], [[4zwm]] – TgOA + PLP <br />
Line 96: Line 97:
**[[5cm0]] – GaBCAT + PLP – ''Geoglobus acetivorans'' <br />
**[[5cm0]] – GaBCAT + PLP – ''Geoglobus acetivorans'' <br />
**[[5e25]] – GaBCAT + PLP + ketoglutarate <br />
**[[5e25]] – GaBCAT + PLP + ketoglutarate <br />
-
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
+
**[[5ce8]] – TuBCAT + PLP – ''Thermoproteus uzoniensis'' <br />
 +
**[[6thq]] – TuBCAT + PLP + norvaline<br />
**[[5u3f]] – MtBCAT + cycloserine <br />
**[[5u3f]] – MtBCAT + cycloserine <br />
**[[6nst]] - PaBCAT (mutant) – ''Pseudomonas aeruginosa''<br />
**[[6nst]] - PaBCAT (mutant) – ''Pseudomonas aeruginosa''<br />
Line 104: Line 106:
**[[6h65]] – TteBCAT + PLP – ''Haliangium ochraceum'' <br />
**[[6h65]] – TteBCAT + PLP – ''Haliangium ochraceum'' <br />
**[[4whx]] – BpBCAT + PLP – ''Burkholderia pseudomallei'' <br />
**[[4whx]] – BpBCAT + PLP – ''Burkholderia pseudomallei'' <br />
 +
**[[7lv7]] – BCAT – ''Giardia lamblia'' <br />
*Aromatic amino acid aminotransferase
*Aromatic amino acid aminotransferase
Line 167: Line 170:
**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]], [[6b6g]] – GABA + inactivator - pig <br />
**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]], [[6b6g]] – GABA + inactivator - pig <br />
-
**[[1sf2]] – EcGABA + PLP <br />
+
**[[1sf2]], [[7jh3]] – EcGABA + PLP <br />
**[[1sff]] – EcGABA + PLP derivative <br />
**[[1sff]] – EcGABA + PLP derivative <br />
**[[1szk]], [[1szs]], [[1szu]] – EcGABA (mutant) + PLP derivative <br />
**[[1szk]], [[1szs]], [[1szu]] – EcGABA (mutant) + PLP derivative <br />
Line 198: Line 201:
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
-
*Alpha-aminoadipate aminotransferase
+
*Alpha-aminoadipate aminotransferase or kynurenine/alpha-aminoadipate aminotransferase
**[[6t8p]], [[6t8q]] - hAADAT + PLP derivative + inhibitor <br />
**[[6t8p]], [[6t8q]] - hAADAT + PLP derivative + inhibitor <br />
Line 262: Line 265:
**[[6jix]] – TOGAT + PLP + Glu – ''Bifidobacterium kashiwanohense'' <br />
**[[6jix]] – TOGAT + PLP + Glu – ''Bifidobacterium kashiwanohense'' <br />
 +
 +
*Diaminopimelate aminotransferase
 +
 +
**[[6oxm]] – DPAT – ''Verrucomicrobium spinosum''<br />
*Glutamine-fructose-6-phosphate aminotransferase
*Glutamine-fructose-6-phosphate aminotransferase
Line 273: Line 280:
**[[6svo]] – hGFPAT + Glu + G6P derivative<br />
**[[6svo]] – hGFPAT + Glu + G6P derivative<br />
**[[6r4i]] – hGFPAT (mutant) + Glu + G6P<br />
**[[6r4i]] – hGFPAT (mutant) + Glu + G6P<br />
-
**[[6r4e]] – hGFPAT + PLP + Glu + G6P<br />
+
**[[6r4e], [[6zmk]]] – hGFPAT + PLP + Glu + G6P<br />
*Aminotransferase
*Aminotransferase
Line 282: Line 289:
**[[6qp1]] – ShAT + inhibitor – ''Staphylococcus hominis''<br />
**[[6qp1]] – ShAT + inhibitor – ''Staphylococcus hominis''<br />
**[[6qp2]] – ShAT + PLP + polyHis<br />
**[[6qp2]] – ShAT + PLP + polyHis<br />
 +
**[[6t3v]] – PsAT + PLP + substrate analog<br />
 +
**[[6u7a]] – MtAT + PLP + PLP derivative + kynurenine<br />
*Aminotransferase class II
*Aminotransferase class II
Line 293: Line 302:
**[[5m49]] – RfAT3 + PLP + azepan derivative<br />
**[[5m49]] – RfAT3 + PLP + azepan derivative<br />
**[[5m4b]], [[5m4d]] – RfAT3 (mutant) + azepan derivative<br />
**[[5m4b]], [[5m4d]] – RfAT3 (mutant) + azepan derivative<br />
-
**[[6k8h]] – AT3 + PLP derivative – ''Sphaerobacter thermophilus''<br />
+
**[[5d95]], [[6k8h]] – AT3 + PLP derivative – ''Sphaerobacter thermophilus''<br />
**[[6io1]] – AT3 + PLP derivative – ''Thermomicrobium roseum''<br />
**[[6io1]] – AT3 + PLP derivative – ''Thermomicrobium roseum''<br />

Revision as of 09:39, 18 March 2021

3D structures of Aminotransferase

Updated on 18-March-2021 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Histidinol-phosphate aminotransferase
    • 1gew, 1iji – EcHPA + PLP – Escherichia coli
    • 1gey, 1fg7 – EcHPA + PLP derivative
    • 1gex, 1fg3 – EcHPA + PLP + histidinol-phosphate
    • 1uu0 – TmHPA + phosphate – Thermotoga maritima
    • 1uu1 – TmHPA + PLP derivative + histidinol-phosphate
    • 1h1c – TmHPA + PLP
    • 1uu2, 2f8j – TmHPA + PLP derivative
    • 3cq4 – CgHPA – Corynebacterium glutamicum
    • 3cq5, 3cq6 – CgHPA + PLP derivative
    • 3ffh – HPA – Listeria innocua
    • 3ftb – HPA + phosphate – Clostridium acetobutylicum
    • 3hdo – HPA – Geobacter metallireducens
    • 4rae – MtHPA – Mycobacterium tuberculosis
    • 4r8d, 5c6u, 5yhv – MtHPA + PLP
  • Ornithine aminotransferase
    • 1oat – hOA + PLP – human
    • 1gbn, 2can, 5vwo, 6oia, 6v8c, 6v8d – hOA + PLP + inhibitor
    • 2oat – hOA + PLP derivative
    • 2byj, 2byl – hOA (mutant) + PLP
    • 7jx9 – hOA + intermediate + inhibitor
    • 5eav – TgOA – Toxoplasma gondii
    • 5eqc, 4zwm – TgOA + PLP
    • 5e5i – TgOA + inactivator
    • 5e3k – TgOA + pentanoic acid derivative
    • 5dj9 – TgOA + gabaculine
  • Acetylornithine aminotransferase
    • 2ord, 2e54 – TmACOAT + PLP
    • 2eh6 – ACOAT + PLP – Aquifex aeolicus
    • 3nx3 – CjACOAT – Campylobacter jejuni
    • 5viu – ACOAT – Elizabethkingia anophelis
    • 6w7x – ACOAT (mutant) – Stenotrophomonas maltophila
    • 4jev – StACOAT + PLP derivative – Salmonella typhimurium
    • 4jey – StACOAT (mutant) + PLP
    • 4jf0, 4f01 – StACOAT (mutant) + PLP derivative
    • 4jew, 4jex, 4jez – StACOAT (mutant) + canaline
  • Succinylornithine aminotransferase
    • 4ade – EcSOAT
    • 4adb, 4adc – EcSOAT + PLP
    • 4add – EcSOAT + PLP + succinylornithine
  • Alanine glyoxylate aminotransferase or serine-pyruvate aminotransferase or 3-hydroxykynurenine transaminase
    • 1h0c, 2yob, 5f9s, 5og0, 6rv1 – hAGA + PLP
    • 4cbr, 4cbs, 5ofy, 5luc – hAGA (mutant) + PLP
    • 1j04, 5hhy, 6rv0 – hAGA + PLP derivative
    • 4i8a – hAGA (mutant) + PLP derivative
    • 3r9a – hAGA + PLP derivative + peroxisomal targeting signal receptor
    • 4kxk, 4kyo – hAGA (mutant) + peroxisomal targeting signal receptor
    • 6mfb – AaAGA + PLP – Aedes aegypti
    • 2huf – AaAGA + PLP derivative
    • 2hui – AaAGA + PLP derivative + glyoxylate
    • 2huu – AaAGA + PLP derivative + alanine
    • 6pk3 – AtAGA + PLP – Arabidopsis thaliana
    • 6pk1 – AtAGA + PLP + pyruvate
    • 1vjo – AGA + PLP - Nostoc
  • D-amino acid aminotransferase
    • 1a0g - BaAAT + PLP derivative – Bacillus
    • 1daa, 4daa - BaAAT + PLP
    • 2dab, 1g2w - BaAAT (mutant) + PLP
    • 2daa, 3daa - BaAAT + PLP derivative
    • 5daa - BaAAT (mutant) + PLP derivative
    • 3lqs - BaAAT + thiophenecarboxylic acid
    • 4m0j - BtAAT – Burkholderia thailandensis
    • 4tm5 - BtAAT + PLP
  • Branched chain amino acid aminotransferase
    • 1ekf, 1ekp, 1ekv – hBCAT + PLP
    • 2hdk, 2hgw, 2hgx, 2hhf, 5mpr, 6prx – hBCAT (mutant) + PLP
    • 1kt8, 1kta – hBCAT + PLP derivative
    • 2alh, 5bwr, 5bwt, 5bwu, 5bwv, 5bwx, 5bww, 5cr5 – hBCAT + PLP + inhibitor
    • 5i60, 5i5y, 5i5x, 5i5w, 5i5v, 5i5u, 5i5t, 5i5s, 5hne – hBCAT + PLP + biaryl amide
    • 2hg8 – hBCAT (mutant) + PLP + methylleucine
    • 4chi – AfBCAT + PLP – Aspergillus fumigatus
    • 4uug – AfBCAT + inhibitor
    • 4cmd – NhBCAT + PLP – Nectria haematococca
    • 4cmf – NhBCAT + inhibitor
    • 5cm0 – GaBCAT + PLP – Geoglobus acetivorans
    • 5e25 – GaBCAT + PLP + ketoglutarate
    • 5ce8 – TuBCAT + PLP – Thermoproteus uzoniensis
    • 6thq – TuBCAT + PLP + norvaline
    • 5u3f – MtBCAT + cycloserine
    • 6nst - PaBCAT (mutant) – Pseudomonas aeruginosa
    • 6jif – PaBCAT + PLP
    • 6gkr – TteBCAT + PLP – Thermobaculum terrenum
    • 6q8e – TteBCAT + PLP derivative
    • 6h65 – TteBCAT + PLP – Haliangium ochraceum
    • 4whx – BpBCAT + PLP – Burkholderia pseudomallei
    • 7lv7 – BCAT – Giardia lamblia
  • Aromatic amino acid aminotransferase
    • 1ay4 – PdAROAT + PLP – Paracoccus dentrificans
    • 1ay5 – PdAROAT + PLP + maleic acid
    • 1ay8, 1ay1 – PdAROAT + PLP + cinnamic acid derivative
    • 2ay2, 2ay3, 2ay4, 2ay5 – PdAROAT + PLP + propionic acid derivative
    • 2ay6, 2ay7, 2ay8 – PdAROAT + PLP + butyric acid derivative
    • 2ay9 – PdAROAT + PLP + valeric acid derivative
    • 4eff – BpAROAT – Burkholderia pseudomallei
    • 4f4e – BpAROAT + PLP derivative
    • 4rkc – PsAROAT + PLP derivative - Psychrobacter
    • 4rkd – PsAROAT + PLP derivative + PLP
    • 6hnb – CaAROAT – Candida albicans
    • 6hnu – CaAROAT + PLP + Phe
  • Tyrosine aminotransferase
    • 3dyd – hTYRAT + PLP
    • 3pdx – mTYRAT + PLP derivative – mouse
    • 3tat – EcTYRAT + PLP
    • 3fsl – EcTYRAT (mutant) + PLP derivative
    • 1bw0 – TYRAT + PLP derivative – Trypanosoma cruzi
    • 4ix8 – TYRAT + PLP derivative – Leishmania infantum
  • Tryptophan aminotransferase
    • 3bwn, 3bwo – AtTRYAT + PLP derivative
  • Beta-phenylalanine aminotransferase
    • 4ao9 – VpPHEAT + PLP – Variovorax paradoxus
    • 4aoa – VpPHEAT + PLP derivative
  • Alanine aminotransferase
    • 3ihj – hALAAT 2 + PLP
    • 3tcm – ALAAT 2 (mutant) + PLP derivative - barley
  • Cysteine aminotransferase
    • 4w91 – CYSAT + PLP – Brucella suis
  • Glutamine aminotransferase
    • 1v2d – TtGLNAT + PLP – Thermus thermophilus
    • 1v2e – TtGLNAT + PLP + keto-methylthiobutyrate
    • 1v2f – TtGLNAT + PLP + phenylpropionate
  • Lysine aminotransferase
    • 2cin – MtLYSAT + PLP
    • 2jje – MtLYSAT (mutant) + PLP
    • 2jjf – MtLYSAT (mutant)
    • 2cjd – MtLYSAT + PLP + lysine
    • 2jjg – MtLYSAT + PLP + inhibitor
    • 2cjg – MtLYSAT + PLP derivative
    • 2cjh – MtLYSAT + PLP + oxoglutarate
    • 2jjh – MtLYSAT (mutant) + PLP + oxoglutarate
  • Gamma-aminobutyrate aminotransferase or 4-aminobutyrate aminotransferase
    • 4zsy, 4zsw, 4y0i, 4y0h, 4y0d, 6b6g – GABA + inactivator - pig
    • 1sf2, 7jh3 – EcGABA + PLP
    • 1sff – EcGABA + PLP derivative
    • 1szk, 1szs, 1szu – EcGABA (mutant) + PLP derivative
    • 3r4t – GABA + PLP derivative – Mycobacterium marinum
    • 4ffc – GABA + PLP derivative – Mycobacterium abscessus
    • 6wj8 – GABA + PLP derivative – Klebsiella pneumoniae
  • ArnB aminotransferase
    • 1mdo - StArnB + PLP derivative
    • 1mdx – StArnB + PLP + oxoglutarate
    • 1mdz – StArnB + PLP + PLP derivative
  • PseC aminotransferase
    • 2fni - HpPseC + PLP – Helicobacter pylori
    • 2fn6 - HpPseC + phosphate
    • 2fnu - HpPseC + PLP derivative + uridine derivative
    • 3hbm - CjPseC (mutant)
    • 3hbn - CjPseC (mutant) + UDP
  • TlmJ aminotransferase
    • 5uid - TlmJ + PLP – Streptoalloteichus hindustanus
  • WbpE aminotransferase
  • Alpha-aminoadipate aminotransferase or kynurenine/alpha-aminoadipate aminotransferase
    • 6t8p, 6t8q - hAADAT + PLP derivative + inhibitor
    • 4je5 - AADAT + PLP derivative + PLP - yeast
    • 2egy, 5eun - TtAADAT + PLP
    • 3cbf, 2zyj - TtAADAT + PLP derivative
    • 2zp7, 2z1y - TtAADAT + PLP + leucine
  • Broad specificity aminotransferase
    • 4wb0 - BsAT – Leishmania mexicana
  • Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • Putrescine aminotransferase
    • 4uoy - EcPAT + PLP
    • 4uox - EcPAT + PLP + putrescine
    • 6gwi - PAT + PLP – Halomonas elongata
  • Omega amino acid-pyruvate aminotransferase
  • C-6’ aminotransferase
    • 6cbo - MeAT – Micromonospora echinospora
    • 5z83 – MeAT + PLP
    • 5z8a – MeAT + PLP + JI-20A
    • 5z8k – MeAT + PLP + neomycin
  • Kynurenine aminotransferase
  • Diaminopelargonic acid aminotransferase
    • 6erk – DPAAT + PLP – Psychrobacter cryohalolentis
    • 6ed7 – EcDPAAT + PLP + inhibitor
  • D-phenylglycine aminotransferase
    • 6dvs – PsDPGAT – Pseudomonas stutzeri
    • 6g1f – PsDPGAT + PLP derivative
  • Aminopentol aminotransferase
    • 6hbs – SmAPAT + PLP – Sphingopykis macrogoltabida
    • 6hbv – SmAPAT + PLP + PLP derivative
  • Taurine:2-oxoglutamate aminotransferase
    • 6jix – TOGAT + PLP + Glu – Bifidobacterium kashiwanohense
  • Diaminopimelate aminotransferase
    • 6oxm – DPAT – Verrucomicrobium spinosum
  • Glutamine-fructose-6-phosphate aminotransferase
    • 6r4f – hGFPAT + G6P
    • 6r4g – hGFPAT + G6P + UDP-GlcNAc
    • 6svp – hGFPAT + Glu + G6P + UDP-GlcNAc
    • 6r4j – hGFPAT (mutant) + Glu + G6P + UDP-GlcNAc
    • 6svm – hGFPAT + Glu + G6P + UDP-GlcNAc + inhibitor
    • 6r4h, 6svq – hGFPAT + Glu + G6P
    • 6svo – hGFPAT + Glu + G6P derivative
    • 6r4i – hGFPAT (mutant) + Glu + G6P
    • [[6r4e], 6zmk] – hGFPAT + PLP + Glu + G6P
  • Aminotransferase
    • 6l1l – BsAT + PLP – Bacillus subtilis
    • 6l1n – BsAT + PLP + Gly
    • 6l1o – BsAT + PLP + PLP derivative + Tyr
    • 6qp1 – ShAT + inhibitor – Staphylococcus hominis
    • 6qp2 – ShAT + PLP + polyHis
    • 6t3v – PsAT + PLP + substrate analog
    • 6u7a – MtAT + PLP + PLP derivative + kynurenine
  • Aminotransferase class II
    • 5z0q – AT2 + PLP – Erwinia tasmaniensis
  • Aminotransferase class III
    • 5ghg, 5ghf – AT3 + PLP derivative – Orchrobactrum anthropi
    • 5m46 – RfAT3 + PLP – Rhizobium freirei
    • 5m49 – RfAT3 + PLP + azepan derivative
    • 5m4b, 5m4d – RfAT3 (mutant) + azepan derivative
    • 5d95, 6k8h – AT3 + PLP derivative – Sphaerobacter thermophilus
    • 6io1 – AT3 + PLP derivative – Thermomicrobium roseum
  • Aminotransferase class IV
    • 4tvi – AT4 + PLP derivative – Brucella abortus


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Joel L. Sussman, Michal Harel

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