Adenosine A2A receptor
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. | + | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. |
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| + | See also: | ||
| + | * [[G protein-coupled receptor]] | ||
| + | *[[Receptor]] | ||
| + | *[[Transmembrane (cell surface) receptors]] | ||
== Structural highlights == | == Structural highlights == | ||
Current revision
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References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
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