Cytokine receptors

Under development!!!

See also Receptor

Cytokine receptors

TNF receptor superfamily

• Tumor necrosis factor receptor

The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The . The CRDs are involved in binding of TNF^[1]. . Water molecules are shown as red spheres.

• TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10

TRAIL-R2 is called DR5. (1d0g).

Colony-stimulating factor receptor

Type I cytokine receptors

• Erythropoietin receptor

The of the blood marrow is part of the hematipoietic cytokine family. This receptor has a single transmembrane domain, that forms a homodimer complex until it is activated by the binding of EPO. This receptor is 484 amino acids long and weigh 52.6 kDa. Once the homodimer is formed after the binding, autophosphorlation of the Jak2 kinases, which activates other cellular processes. This transmembrane receptor has two extracellular domains. This receptor has two disulfide bonds that are formed from 4 cystine residues, . The intracellular domain of this receptor does not possess any enzymatic activity like other receptors. When EPO comes in contact with the extracellular domains form a ligand bond. The extracellular sinding site 1 and Binding site 2 are composed of . When EPO binds, all loops on D1 and D2 of binding site one form a bind with EPO. However loop 4 of D1 on binding site 2 does not participate in the binding of EPO ^[2]. After the biniding of EPO, 8 tyrosine residues are phosphoralated which activates the . This kinase helps regulate the transcription of different genes and expression of other proteins.

(PDB code 1cn4).^[3]

• Prolactin receptor

Type II cytokine receptors

Interferon receptors

• Interferon receptor
• Structural linkage between ligand discrimination and receptor activation by type I interferons
• Multiple sclerosis and Interferon Receptors

Interleukin receptors

Interleukin-20 receptor:

• Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1