Lipase lid morph
From Proteopedia
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*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />). | *<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />). | ||
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| + | A second morph<ref>This is a [[Jmol/Storymorph|rigid body morph]] based on the superoposition in PDB file is [[Image:1TRH_1LPM.pdb]].</ref> shows a <scene name='49/493694/Storymorph/1'>different path</scene> between the same initial and final experimental structures. | ||
==See Also== | ==See Also== | ||
Revision as of 09:47, 10 August 2021
For an introduction to the structure and function of lipase, please see the article Lipase. This Lipase lid morph article is a supplement to the main article on Lipase.
Candida rugosa lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" (residues 66-92[1]) closed (1trh) or open (1lpm)[1].
- Closed LID ().
- LID with inhibitor (1R)-menthyl hexyl phosphonate (C O P).
A morph[2] shows the lid opening and closing.
- (LID).
- (LID, catalytic triad: Ser209, Glu341, and His449[1]).
When the lid is closed, the enzyme surface is largely Polar. When the lid opens, a Hydrophobic pocket is exposed with the catalytic triad in the bottom.
- (Polar, Hydrophobic, catalytic triad: Ser209, Glu341, and His449[1]).
A second morph[3] shows a between the same initial and final experimental structures.
See Also
- Lipase, the main article in Proteopedia.
- Molecular Playground/Pancreatic Lipase
- Lipase in Wikipedia
Notes and References
- ↑ 1.0 1.1 1.2 1.3 Grochulski P, Li Y, Schrag JD, Cygler M. Two conformational states of Candida rugosa lipase. Protein Sci. 1994 Jan;3(1):82-91. PMID:8142901
- ↑ This is a linear interpolation morph. The 14-model PDB file is Image:Morph-linear-1trh-1lpm.pdb.gz.
- ↑ This is a rigid body morph based on the superoposition in PDB file is Image:1TRH 1LPM.pdb.
