Cytokine receptors

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<scene name='70/705725/Cv/3'>Human erythropoietin receptor with erythropoietin</scene> (PDB code [[1cn4]]).<ref>PMID:9774108</ref>
<scene name='70/705725/Cv/3'>Human erythropoietin receptor with erythropoietin</scene> (PDB code [[1cn4]]).<ref>PMID:9774108</ref>
*[[Prolactin receptor]]
*[[Prolactin receptor]]
 +
<scene name='74/749401/Cv/5'>Human prolactin receptor complex with prolactin, Na+ and Cl-</scene> (PDB code [[3mzg]]). The interaction between PRLR and prolactin is strongly pH-dependent and is critically dependent on <scene name='74/749401/Cv/6'>two histidine residues located at PRLP and on prolactin</scene><ref>PMID:20889499</ref>. Water molecules are shown as red spheres. <scene name='74/749401/Cv/7'>Na coordination site is situated between PRLR and prolactin</scene>.
====Type II cytokine receptors====
====Type II cytokine receptors====
=====Interferon receptors=====
=====Interferon receptors=====

Revision as of 15:57, 12 August 2021

2 extracellular domains of Human erythropoietin receptor (green) complex with erythropoietin (magenta) (PDB code 1cn4)

Drag the structure with the mouse to rotate

References

  1. ↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750
  2. ↑ Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Mar 14. PMID:23493555 doi:http://dx.doi.org/10.1073/pnas.1219457110
  3. ↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:http://dx.doi.org/10.1016/j.str.2015.06.019
  4. ↑ Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 1;395(6701):511-6. PMID:9774108 doi:http://dx.doi.org/10.1038/26773
  5. ↑ Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 1;395(6701):511-6. PMID:9774108 doi:http://dx.doi.org/10.1038/26773
  6. ↑ Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME. Two independent histidines, one in human prolactin and one in its receptor, are critical for pH dependent receptor recognition and activation. J Biol Chem. 2010 Sep 30. PMID:20889499 doi:10.1074/jbc.M110.172072

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