2cdx
From Proteopedia
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<StructureSection load='2cdx' size='340' side='right'caption='[[2cdx]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> | <StructureSection load='2cdx' size='340' side='right'caption='[[2cdx]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2cdx]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDX FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdx OCA], [https://pdbe.org/2cdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdx RCSB], [https://www.ebi.ac.uk/pdbsum/2cdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/3SA1_NAJAT 3SA1_NAJAT]] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity). It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165). It also binds with high affinity to heparin (PubMed:17685633). It also causes skeletal muscle necrosis after intramuscular injection into mice (PubMed:8342169).[UniProtKB:P60301]<ref>PMID:8342169</ref> <ref>PMID:8448165</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |
Revision as of 20:34, 20 October 2021
STRUCTURE OF COBRA CARDIOTOXIN CTXI AS DERIVED FROM NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DISTANCE GEOMETRY CALCULATIONS
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