Sandbox Reserved 1694

From Proteopedia

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== Important amino acids==
== Important amino acids==
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These <scene name='89/892737/Amino_acids_rotating/2'>Amino acids</scene> play an extensive role in interactions between 1-PO4 and 2-PO4 of the substrate to the active site. Also, there are a few different amino acids (<scene name='89/892737/Amino_acids_for_ring/1'>amino acids</scene>) that interact with the inositol ring and help reinforce the binding of the Ins(1,4)P2.
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These <scene name='89/892737/Amino_acids_rotating/2'>amino acids</scene> play an extensive role in interactions between 1-PO4 and 2-PO4 of the substrate to the active site. Also, there are a few different amino acids (<scene name='89/892737/Amino_acids_for_ring/1'>amino acids</scene>) that interact with the inositol ring and help reinforce the binding of the Ins(1,4)P2.
<ref>PMID:33172890</ref>
<ref>PMID:33172890</ref>
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== Other important features ==
== Other important features ==
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<scene name='89/892737/Alanine/1'>mutation in D54</scene>
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In the structure INPP1^D54A there is a mutation in D54 to A54 <scene name='89/892737/Alanine/1'>mutation in D54</scene>
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Revision as of 14:34, 7 November 2021

This Sandbox is Reserved from 10/01/2021 through 01/01//2022 for use in Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1690 through Sandbox Reserved 1699.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Your Heading Here (maybe something like 'Structure')

Inositol Polyphosphate 1-Phosphatase structure (INPP1) D54A mutant in complex with inositol (1,4)-bisphosphate

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Dollins DE, Xiong JP, Endo-Streeter S, Anderson DE, Bansal VS, Ponder JW, Ren Y, York JD. A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase. J Biol Chem. 2020 Nov 10. pii: RA120.014057. doi: 10.1074/jbc.RA120.014057. PMID:33172890 doi:http://dx.doi.org/10.1074/jbc.RA120.014057
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