Sandbox Reserved 1694

From Proteopedia

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These <scene name='89/892737/Amino_acids_rotating/3'>amino acids</scene> play an extensive role in interactions between 1-PO4 and 2-PO4 of the substrate to the active site. Also, there are a few different amino acids (<scene name='89/892737/Amino_acids_for_ring/1'>amino acids</scene>) that interact with the inositol ring and help reinforce the binding of the Ins(1,4)P2.
These <scene name='89/892737/Amino_acids_rotating/3'>amino acids</scene> play an extensive role in interactions between 1-PO4 and 2-PO4 of the substrate to the active site. Also, there are a few different amino acids (<scene name='89/892737/Amino_acids_for_ring/1'>amino acids</scene>) that interact with the inositol ring and help reinforce the binding of the Ins(1,4)P2.
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<ref>PMID:33172890</ref>
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<ref name="dollins">PMID:33172890</ref>
== Structural highlights ==
== Structural highlights ==
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== Other important features ==
== Other important features ==
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In the structure INPP1D54A, there is a mutation in the amino acid aspartic acid (D)54 and causes it to change to alanine (A)54 (<scene name='89/892737/Alanine/1'>mutation in D54</scene>). This mutation does not impact the substrate affinity but does decrease the activity of INPP1. <ref>PMID:33172890</ref>
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In the structure INPP1D54A, there is a mutation in the amino acid aspartic acid (D)54 and causes it to change to alanine (A)54 (<scene name='89/892737/Alanine/1'>mutation in D54</scene>). This mutation does not impact the substrate affinity but does decrease the activity of INPP1. <ref name="dollins" />
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</StructureSection>
</StructureSection>
== References ==
== References ==
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<references/>
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<references />

Revision as of 19:47, 7 November 2021

This Sandbox is Reserved from 10/01/2021 through 01/01//2022 for use in Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1690 through Sandbox Reserved 1699.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

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Inositol Polyphosphate 1-Phosphatase structure (INPP1) D54A mutant in complex with inositol (1,4)-bisphosphate

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ 3.0 3.1 Dollins DE, Xiong JP, Endo-Streeter S, Anderson DE, Bansal VS, Ponder JW, Ren Y, York JD. A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase. J Biol Chem. 2020 Nov 10. pii: RA120.014057. doi: 10.1074/jbc.RA120.014057. PMID:33172890 doi:http://dx.doi.org/10.1074/jbc.RA120.014057
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