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Ceramide

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Current revision (15:16, 5 December 2021) (edit) (undo)
 
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<StructureSection load='' scene='Acid-beta-glucosidase/Overview2/2' size='350' caption='Human acid-β-glucosidase (PDB code [[1ogs]])'
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<StructureSection load='' scene='89/898345/Cv/1' size='350' caption='Ceramide'
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*[[Acid-beta-glucosidase]] or '''glucosylceramidase''' is a lysozomal enzyme (EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45]), which cleaves glucosylceramide to glucose and ceramide. It catalyzes hydrolysis of the sphingolipid, <scene name='Acid-beta-glucosidase/Cv/3'>glucosylceramide (GlcCer)</scene>, to <scene name='Acid-beta-glucosidase/Cv/2'>glucose and ceramide</scene> at the acidic pH prevailing within the lysosome. <scene name='Acid-beta-glucosidase/Cv/4'>Click here to see animation of this reaction</scene>.
*[[Acid-beta-glucosidase]] or '''glucosylceramidase''' is a lysozomal enzyme (EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45]), which cleaves glucosylceramide to glucose and ceramide. It catalyzes hydrolysis of the sphingolipid, <scene name='Acid-beta-glucosidase/Cv/3'>glucosylceramide (GlcCer)</scene>, to <scene name='Acid-beta-glucosidase/Cv/2'>glucose and ceramide</scene> at the acidic pH prevailing within the lysosome. <scene name='Acid-beta-glucosidase/Cv/4'>Click here to see animation of this reaction</scene>.

Current revision

Ceramide

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References

  1. Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563

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Alexander Berchansky

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