User:Anielle Salviano de Almeida Ferrari/Sandbox 1
From Proteopedia
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<Structure load='5W10' size='350' frame='true' align='right' side='right'caption='[[5W10]], [[Resolution|resolution]] 2.15Å' caption='Lcd1 GAF domain in complex with cAMP ligand. Method: X-Ray Diffraction. Resolution: 2.15 Å' scene='' /> | <Structure load='5W10' size='350' frame='true' align='right' side='right'caption='[[5W10]], [[Resolution|resolution]] 2.15Å' caption='Lcd1 GAF domain in complex with cAMP ligand. Method: X-Ray Diffraction. Resolution: 2.15 Å' scene='' /> | ||
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| + | == Introduction == | ||
The bacterium Leptospira interrogans serovar Copenhageni causes leptospirosis disease, a worldwide zoonosis that affects various mammals including humans [20]. In 5–15% of leptospirosis cases, the clinical symptoms may progress to a severe disease condition, which can cause jaundice, renal failure, meningitis, hypotension, bleeding, multiple organ failure, pulmonary hemorrhages and, in some cases, death [21,22]. The ability of some Leptospira species to grow in different conditions, such as in soil, water, and in different mammalian organs and the bloodstream, suggests that the bacteria should possess different signaling pathways to sense the external environment in order to appropriately modify bacterial biochemistry, physiology, and behavior. Therefore, we can expect that c-di-GMP will have an important role in the Leptospira life cycle. However, to date, almost nothing is known about c-di-GMP signaling in Leptospira. | The bacterium Leptospira interrogans serovar Copenhageni causes leptospirosis disease, a worldwide zoonosis that affects various mammals including humans [20]. In 5–15% of leptospirosis cases, the clinical symptoms may progress to a severe disease condition, which can cause jaundice, renal failure, meningitis, hypotension, bleeding, multiple organ failure, pulmonary hemorrhages and, in some cases, death [21,22]. The ability of some Leptospira species to grow in different conditions, such as in soil, water, and in different mammalian organs and the bloodstream, suggests that the bacteria should possess different signaling pathways to sense the external environment in order to appropriately modify bacterial biochemistry, physiology, and behavior. Therefore, we can expect that c-di-GMP will have an important role in the Leptospira life cycle. However, to date, almost nothing is known about c-di-GMP signaling in Leptospira. | ||
Revision as of 20:42, 6 December 2021
Contents |
Leptospira cAMP-dependent DGC 1 (Lcd1)
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Introduction
The bacterium Leptospira interrogans serovar Copenhageni causes leptospirosis disease, a worldwide zoonosis that affects various mammals including humans [20]. In 5–15% of leptospirosis cases, the clinical symptoms may progress to a severe disease condition, which can cause jaundice, renal failure, meningitis, hypotension, bleeding, multiple organ failure, pulmonary hemorrhages and, in some cases, death [21,22]. The ability of some Leptospira species to grow in different conditions, such as in soil, water, and in different mammalian organs and the bloodstream, suggests that the bacteria should possess different signaling pathways to sense the external environment in order to appropriately modify bacterial biochemistry, physiology, and behavior. Therefore, we can expect that c-di-GMP will have an important role in the Leptospira life cycle. However, to date, almost nothing is known about c-di-GMP signaling in Leptospira.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
