User:Anielle Salviano de Almeida Ferrari/Sandbox 1
From Proteopedia
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== Introduction == | == Introduction == | ||
The [https://en.wikipedia.org/wiki/Leptospirosis leptospirosis] is caused by [https://en.wikipedia.org/wiki/Spirochaete spirochaetes] of pathogenic species of genus [https://en.wikipedia.org/wiki/Leptospira ''Leptospira''] and is a emerging zoonotic disease worldwide <ref>DOI 10.1016/j.jmb.2017.06.002</ref> <ref>DOI 10.1371/journal.pntd.0007270</ref>. | The [https://en.wikipedia.org/wiki/Leptospirosis leptospirosis] is caused by [https://en.wikipedia.org/wiki/Spirochaete spirochaetes] of pathogenic species of genus [https://en.wikipedia.org/wiki/Leptospira ''Leptospira''] and is a emerging zoonotic disease worldwide <ref>DOI 10.1016/j.jmb.2017.06.002</ref> <ref>DOI 10.1371/journal.pntd.0007270</ref>. | ||
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| - | According to the [https://www.who.int/ World Health Organization (WHO)], approximately 1 million people become infected with leptospiras per year and 60,000 die from the disease worldwide (Costa et al., 2015; reviewed by Picardeau, 2017). The highest incidence is in tropical countries, as the climate and humidity favor the proliferation of this bacteria. In 5–15% of leptospirosis cases, clinical symptoms can progress to severe disease, which can lead to jaundice, renal failure, meningitis, hypotension, bleeding, multiple organ failure, pulmonary hemorrhage, and, in some cases, death [21 , 22]. The ability of some ''Leptospira'' species to grow in different conditions, such as in soil, water and in different mammalian organs and in the bloodstream, suggests that the bacteria must have different signaling pathways to detect the external environment in order to properly modify the bacterial biochemistry. physiology and behavior. Therefore, we can expect c-di-GMP to play an important role in ''Leptospira'' life cycle. However, to date, almost nothing is known about c-di-GMP signaling in Leptospira. | ||
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| + | According to the [https://www.who.int/ World Health Organization (WHO)], approximately 1 million people become infected with leptospiras per year and 60,000 die from the disease worldwide (Costa et al., 2015; reviewed by Picardeau, 2017). The highest incidence is in tropical countries, as the climate and humidity favor the proliferation of this bacteria. In 5–15% of leptospirosis cases can progress to severe disease, which can lead to jaundice, renal failure, bleeding, multiple organ failure, pulmonary hemorrhage, and, in some cases, death [21, 22]. The ability of some ''Leptospira'' species to grow in different conditions, such as in soil, water and in different mammalian organs and in the bloodstream, suggests that the bacteria must have different signaling pathways to detect the external environment and modulate its gene expression. One way to respond to environmental changes and modulate gene expression is through the production of bis (3 ′, 5 ′) - cyclic diguanylic acid, known as cyclic di-GMP (c-di-GMP). | ||
| + | However, to date, almost nothing is known about c-di-GMP signaling in Leptospira. | ||
Revision as of 19:32, 7 December 2021
Contents |
Leptospira cAMP-dependent DGC 1 (Lcd1)
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Introduction
The leptospirosis is caused by spirochaetes of pathogenic species of genus Leptospira and is a emerging zoonotic disease worldwide [1] [2].
According to the World Health Organization (WHO), approximately 1 million people become infected with leptospiras per year and 60,000 die from the disease worldwide (Costa et al., 2015; reviewed by Picardeau, 2017). The highest incidence is in tropical countries, as the climate and humidity favor the proliferation of this bacteria. In 5–15% of leptospirosis cases can progress to severe disease, which can lead to jaundice, renal failure, bleeding, multiple organ failure, pulmonary hemorrhage, and, in some cases, death [21, 22]. The ability of some Leptospira species to grow in different conditions, such as in soil, water and in different mammalian organs and in the bloodstream, suggests that the bacteria must have different signaling pathways to detect the external environment and modulate its gene expression. One way to respond to environmental changes and modulate gene expression is through the production of bis (3 ′, 5 ′) - cyclic diguanylic acid, known as cyclic di-GMP (c-di-GMP). However, to date, almost nothing is known about c-di-GMP signaling in Leptospira.
Function
Disease
Relevance
Structural highlights
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</StructureSection>
References
- ↑ da Costa Vasconcelos FN, Maciel NK, Favaro DC, de Oliveira LC, Barbosa AS, Salinas RK, de Souza RF, Farah CS, Guzzo CR. Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate Cyclase from Pathogenic Leptospira Species. J Mol Biol. 2017 Jul 21;429(15):2337-2352. doi: 10.1016/j.jmb.2017.06.002. Epub, 2017 Jun 7. PMID:28601495 doi:http://dx.doi.org/10.1016/j.jmb.2017.06.002
- ↑ Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MKN, Amran F, Masuzawa T, Nakao R, Amara Korba A, Bourhy P, Veyrier FJ, Picardeau M. Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007270. doi:, 10.1371/journal.pntd.0007270. eCollection 2019 May. PMID:31120895 doi:http://dx.doi.org/10.1371/journal.pntd.0007270
