User:Anielle Salviano de Almeida Ferrari/Sandbox 1

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Revision as of 01:18, 8 December 2021

Lcd1 GAF domain in complex with cAMP ligand. Method: X-Ray Diffraction. Resolution: 2.15 Å

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The leptospirosis is caused by spirochaetes of pathogenic species of genus Leptospira and is a emerging zoonotic disease worldwide ^[1]

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 The [https://en.wikipedia.org/wiki/Leptospirosis leptospirosis] is caused by [https://en.wikipedia.org/wiki/Spirochaete spirochaetes] of pathogenic species of genus [https://en.wikipedia.org/wiki/Leptospira ''Leptospira''] and is a emerging zoonotic disease worldwide <ref>DOI 10.1016/j.jmb.2017.06.002<ref/><ref>DOI 10.1371/journal.pntd.0007270<ref/>.
-According to the [https://www.who.int/ World Health Organization (WHO)], approximately 1 million people become infected with leptospiras per year and 60,000 die from the disease worldwide <ref>DOI 10.1371/journal.pntd.0003898</ref>. The ability of some ''Leptospira'' species to grow in different conditions, such as in soil, water and in different mammalian organs and in the bloodstream, suggests that the bacteria must have different signaling pathways to detect the external environment and modulate its gene expression. One way to respond to environmental changes and modulate gene expression is through the production of bis (3 ′, 5 ′) - cyclic diguanylic acid, known as cyclic di-GMP (c-di-GMP) <ref name="da Costa Vasconcelos"/>. However, to date, almost nothing is known about c-di-GMP signaling in ''Leptospira''<ref name="da Costa Vasconcelos"/>.
-<ref name:"[3]"> 10.1016/j.jmb.2017.06.002 <ref/>
-<ref name:"[4]"> DOI 10.3389/fmicb.2018.00764 <ref/>
-<ref name:"[5]"> DOI 10.1038/s41522-020-0134-1 <ref/>
-<ref name:"[6]"> 10.1038/s41467-021-22492-7 <ref/>
-<ref name="Liang"/>