1fzc

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[[Image:1fzc.gif|left|200px]]
[[Image:1fzc.gif|left|200px]]
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{{Structure
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|PDB= 1fzc |SIZE=350|CAPTION= <scene name='initialview01'>1fzc</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1fzc", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzc OCA], [http://www.ebi.ac.uk/pdbsum/1fzc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fzc RCSB]</span>
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'''CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS'''
'''CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS'''
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[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
[[Category: Veerapandian, L.]]
[[Category: Veerapandian, L.]]
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[[Category: blood coagulation]]
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[[Category: Blood coagulation]]
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[[Category: crosslinking]]
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[[Category: Crosslinking]]
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[[Category: plasma protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:33:13 2008''
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Revision as of 13:56, 2 May 2008

Image:1fzc.gif

Template:STRUCTURE 1fzc

CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS


Overview

Factor XIII-cross-linked fragment D (double-D) from human fibrin was crystallized in the presence of two different peptide ligands and the X-ray structure determined at 2.3 A. The peptide Gly-Pro-Arg-Pro-amide, which is an analogue of the knob exposed by the thrombin-catalyzed removal of fibrinopeptide A, was found to reside in the gamma-chain holes, and the peptide Gly-His-Arg-Pro-amide, which corresponds to the beta-chain knob, was found in the homologous beta-chain holes. The structure shows for the first time that the beta-chain knob does indeed bind to a homologous hole on the beta-chain. The gamma- and beta-chain holes are structurally very similar, and it is remarkable they are able to distinguish between these two peptides that differ by a single amino acid. Additionally, we have found that the beta-chain domain, like its gamma-chain counterpart, binds calcium.

About this Structure

1FZC is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1FZC with [Fibrin]. Full crystallographic information is available from OCA.

Reference

Crystal structure of fragment double-D from human fibrin with two different bound ligands., Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF, Biochemistry. 1998 Jun 16;37(24):8637-42. PMID:9628725 Page seeded by OCA on Fri May 2 16:56:06 2008

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