3ckl
From Proteopedia
(Difference between revisions)
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==Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol== | ==Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol== | ||
| - | <StructureSection load='3ckl' size='340' side='right' caption='[[3ckl]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3ckl' size='340' side='right'caption='[[3ckl]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1B1, ST1B2, SULT1B2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1B1, ST1B2, SULT1B2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [https://pdbe.org/3ckl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [https://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckl ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bochkarev, A]] | [[Category: Bochkarev, A]] | ||
Revision as of 07:59, 27 January 2022
Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol
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Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Bountra, C | Dong, A | Edwards, A M | Kozieradzki, I | Loppnau, P | Min, J | Pan, P W | Structural genomic | Tempel, W | Weigelt, J | Cytoplasm | Human cytosolic sulfotransferase | Lipid metabolism | Polymorphism | Resveratrol | Sgc | Steroid metabolism | Sult1b1 | Transferase
