7sb8
From Proteopedia
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==d(GA(CGA)5) parallel-stranded homo-duplex== | ==d(GA(CGA)5) parallel-stranded homo-duplex== | ||
| - | <StructureSection load='7sb8' size='340' side='right'caption='[[7sb8]]' scene=''> | + | <StructureSection load='7sb8' size='340' side='right'caption='[[7sb8]], [[Resolution|resolution]] 1.32Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SB8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7sb8]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SB8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sb8 OCA], [https://pdbe.org/7sb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sb8 RCSB], [https://www.ebi.ac.uk/pdbsum/7sb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sb8 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7sb9|7sb9]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sb8 OCA], [https://pdbe.org/7sb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sb8 RCSB], [https://www.ebi.ac.uk/pdbsum/7sb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sb8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DNA can adopt noncanonical structures that have important biological functions while also providing structural diversity for applications in nanotechnology. Here, the crystal structures of two oligonucleotides composed of d(CGA) triplet repeats in the parallel-stranded duplex form are described. The structure determination of four unique d(CGA)-based parallel-stranded duplexes across two crystal structures has allowed the structural parameters of d(CGA) triplets in the parallel-stranded duplex form to be characterized and established. These results show that d(CGA) units are highly uniform, but that each strand in the duplex is structurally unique and has a distinct role in accommodating structural asymmetries induced by the C-CH(+) base pair. | ||
| + | |||
| + | The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands.,Luteran EM, Paukstelis PJ Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):299-309. doi:, 10.1107/S2059798322000304. Epub 2022 Feb 18. PMID:35234144<ref>PMID:35234144</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7sb8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Luteran | + | [[Category: Luteran, E M]] |
| - | [[Category: Paukstelis | + | [[Category: Paukstelis, P J]] |
| + | [[Category: Dna]] | ||
| + | [[Category: Non-canonical dna]] | ||
| + | [[Category: Parallel-stranded duplex]] | ||
| + | [[Category: Triplet repeat dna]] | ||
Revision as of 07:23, 16 March 2022
d(GA(CGA)5) parallel-stranded homo-duplex
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