Sandbox Reserved 1726

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The tumor necrosis factor-like domain interacts with the three helix bundle-like domain to begin the conformational changes associated with ligand binding. The three helix bundle-like domain's alpha helix interacts with the helix alpha-1' and beta strand A-1'. This domain also assists in mediating ligand binding with the epidermal growth factor-like domain.
The tumor necrosis factor-like domain interacts with the three helix bundle-like domain to begin the conformational changes associated with ligand binding. The three helix bundle-like domain's alpha helix interacts with the helix alpha-1' and beta strand A-1'. This domain also assists in mediating ligand binding with the epidermal growth factor-like domain.
==== Epidermal Growth Factor-like Domain ====
==== Epidermal Growth Factor-like Domain ====
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The epidermal growth factor-like domain is very malleable and repositioning of this domain is essential for activation of the protein. This domain is able to undergo conformational changes with the ligand bound and when in contact with the tumor necrosis factor-like domain.
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The epidermal growth factor-like domain is very malleable and repositioning of this domain is essential for activation of the protein. This domain is able to undergo conformational changes with the ligand bound and when in contact with the tumor necrosis factor-like domain.
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=== Binding Site ===
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The binding site of Anaplastic Lymphoma Kinase is approximately from E859 to D1006 on one monomer. This site doesn't start out surrounding the ligand, instead the proximity of the ligand allows conformational changes across the protein.
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=== Dimerization of Anaplastic Lymphoma Kinase ===
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To achieve
== Function ==
== Function ==

Revision as of 19:05, 17 March 2022

This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.
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Anaplastic Lymphoma Kinase

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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