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2vbp

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<StructureSection load='2vbp' size='340' side='right'caption='[[2vbp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2vbp' size='340' side='right'caption='[[2vbp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vbp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/A._nidulans A. nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VBP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vbp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/A._nidulans A. nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VBP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VB1:N^6^-[(1R)-2-{[(1S)-1-CARBOXYPROPYL]AMINO}-2-OXO-1-(SULFANYLMETHYL)ETHYL]-6-OXO-L-LYSINE'>VB1</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VB1:N^6^-[(1R)-2-{[(1S)-1-CARBOXYPROPYL]AMINO}-2-OXO-1-(SULFANYLMETHYL)ETHYL]-6-OXO-L-LYSINE'>VB1</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bk0|1bk0]], [[1blz|1blz]], [[1hb2|1hb2]], [[1hb3|1hb3]], [[1hb4|1hb4]], [[1obn|1obn]], [[1odm|1odm]], [[1odn|1odn]], [[1qiq|1qiq]], [[1qje|1qje]], [[1qjf|1qjf]], [[1uzw|1uzw]], [[1w03|1w03]], [[1w06|1w06]], [[1w3x|1w3x]], [[2bu9|2bu9]], [[2ivi|2ivi]], [[2ivj|2ivj]], [[2vbb|2vbb]], [[1hb1|1hb1]], [[1ips|1ips]], [[1oc1|1oc1]], [[1w04|1w04]], [[1w05|1w05]], [[1w3v|1w3v]], [[2bjs|2bjs]], [[2jb4|2jb4]], [[2vau|2vau]], [[2vbd|2vbd]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bk0|1bk0]], [[1blz|1blz]], [[1hb2|1hb2]], [[1hb3|1hb3]], [[1hb4|1hb4]], [[1obn|1obn]], [[1odm|1odm]], [[1odn|1odn]], [[1qiq|1qiq]], [[1qje|1qje]], [[1qjf|1qjf]], [[1uzw|1uzw]], [[1w03|1w03]], [[1w06|1w06]], [[1w3x|1w3x]], [[2bu9|2bu9]], [[2ivi|2ivi]], [[2ivj|2ivj]], [[2vbb|2vbb]], [[1hb1|1hb1]], [[1ips|1ips]], [[1oc1|1oc1]], [[1w04|1w04]], [[1w05|1w05]], [[1w3v|1w3v]], [[2bjs|2bjs]], [[2jb4|2jb4]], [[2vau|2vau]], [[2vbd|2vbd]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopenicillin-N_synthase Isopenicillin-N synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.1 1.21.3.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isopenicillin-N_synthase Isopenicillin-N synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.1 1.21.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbp OCA], [http://pdbe.org/2vbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vbp RCSB], [http://www.ebi.ac.uk/pdbsum/2vbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vbp OCA], [https://pdbe.org/2vbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vbp RCSB], [https://www.ebi.ac.uk/pdbsum/2vbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vbp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IPNS_EMENI IPNS_EMENI]] Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin.
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[[https://www.uniprot.org/uniprot/IPNS_EMENI IPNS_EMENI]] Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 12:43, 23 March 2022

Isopenicillin N synthase with substrate analogue L,L,L-ACAB (unexposed)

PDB ID 2vbp

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