Sandbox Reserved 1723
From Proteopedia
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<StructureSection load='' size='350' frame='true' side='right' caption='MRGPRX2 7S8L' scene='90/904327/Overviewfrontpage/1'> | <StructureSection load='' size='350' frame='true' side='right' caption='MRGPRX2 7S8L' scene='90/904327/Overviewfrontpage/1'> | ||
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| - | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== G-Protein Coupled Receptors == | == G-Protein Coupled Receptors == | ||
| - | [https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane proteins. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary | + | [https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane proteins. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers <ref name="Thal">Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z</ref>. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the rhodopsin family (class A, 701 members), the secretin family (class B, 15 members), the adhesion family (24 members), the glutamate family (class C, 15 members), and the frizzled/taste family (class F, 24 members)². All of the families have a similar transmembrane (TM) domain consisting of seven ɑ-helices complexed with intracellular G proteins. |
== Class A GCPRs == | == Class A GCPRs == | ||
=== MRGPRs === | === MRGPRs === | ||
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| - | ==== MRGPRX2 General ==== | ||
Structure with <scene name='90/904327/Overview_x2_c/1'>cortistatin</scene> | Structure with <scene name='90/904327/Overview_x2_c/1'>cortistatin</scene> | ||
Revision as of 23:29, 28 March 2022
| This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729. |
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Human Itch GPCR
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References
- ↑ Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z
