Methionine synthase

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<StructureSection load='1k7y' size='310' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1k7y' size='310' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page '''Kia Yang/MS'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.</StructureSection>
 
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EC: 2.1.1.13
EC: 2.1.1.13
PDB ID: 1K7Y
PDB ID: 1K7Y
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This is a default text for your page '''Kia Yang/MS'''.</StructureSection>
[[Image:Homocysteine-methionine.jpeg]]
[[Image:Homocysteine-methionine.jpeg]]
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== Function ==
== Function ==
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Methionine synthase methylates homocysteine to methionine.
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Methionine synthase methylates homocysteine to methionine <ref>DOI: 10.1038/nature10916</ref>.
== Vitamin B-12 ==
== Vitamin B-12 ==

Revision as of 14:58, 30 March 2022

Contents

Methionine synthase

This page is being worked on during the Spring 2022 semester.

Caption for this structure

Drag the structure with the mouse to rotate

Image:Homocysteine-methionine.jpeg

Function

Methionine synthase methylates homocysteine to methionine [1].

Vitamin B-12

Oxidation States of Cobalamin

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>

References

[2] [3]

  1. Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
  2. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML. Domain alternation switches B(12)-dependent methionine synthase to the activation conformation. Nat Struct Biol. 2002 Jan;9(1):53-6. PMID:11731805 doi:10.1038/nsb738
  3. Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916

Proteopedia Page Contributors and Editors (what is this?)

Kia Yang, Karsten Theis, Michal Harel, Anna Postnikova, Michael O'Shaughnessy

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