Talk:Methylenetetrahydrofolate reductase

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Textbook chapter on folate reactions: [https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Book%3A_Organic_Chemistry_with_a_Biological_Emphasis_v2.0_(Soderberg)/17%3A_The_Organic_Chemistry_of_Vitamins/17.05%3A_Folate Chapter 17.5]
Textbook chapter on folate reactions: [https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Book%3A_Organic_Chemistry_with_a_Biological_Emphasis_v2.0_(Soderberg)/17%3A_The_Organic_Chemistry_of_Vitamins/17.05%3A_Folate Chapter 17.5]
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Textbook on ping pong mechanisms: [https://chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Enzymes/Enzymatic_Kinetics/Ping-pong_mechanisms Libretext again]
1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound.
1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound.

Revision as of 13:04, 31 March 2022

Textbook chapter on folate reactions: Chapter 17.5

Textbook on ping pong mechanisms: Libretext again

1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound.

The paper is behind a paywall, but here is the link to the abstract: [1]

Biochemistry of the enzyme: https://www.researchgate.net/profile/Elizabeth-Trimmer/publication/232764343_Methylenetetrahydrofolate_Reductase_Biochemical_Characterization_and_Medical_Significance/links/5541077d0cf232222731506c/Methylenetetrahydrofolate-Reductase-Biochemical-Characterization-and-Medical-Significance.pdf


5 methyl folate as dietary supplement: [2]

Making the supplement: [3]

[1]

[2]

  1. Gilbody S, Lewis S, Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol. 2007 Jan 1;165(1):1-13. doi: 10.1093/aje/kwj347. Epub 2006 Oct, 30. PMID:17074966 doi:http://dx.doi.org/10.1093/aje/kwj347
  2. Levin BL, Varga E. MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016, Apr 30. PMID:27130656 doi:http://dx.doi.org/10.1007/s10897-016-9956-7

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