Methionine synthase

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Revision as of 16:30, 2 April 2022

Methionine synthase

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Methionine is an essential amino acid required in order for our bodies to have healthy cell and tissue growth. Unfortunately, it is not naturally derived and dependent on our diets. Methionine synthase methylates homocysteine, another amino acid obtained typically by any meat we consume, to methionine^[1].

EC: 2.1.1.13

PDB ID: 1K7Y

The change from homocysteine to methionine is one methyl group on N-5 donated from methyltetrahydrofolate (MTHF), a product of Methylenetetrahydrofolate reductase (MTHFR), with a protein-bound B-12 vitamin Cobalamin as the methyl carrier.

Vitamin B-12

Oxidation States of Cobalamin

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Structural highlights

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References

^[2]

1. ↑ Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
2. ↑ Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML. Domain alternation switches B(12)-dependent methionine synthase to the activation conformation. Nat Struct Biol. 2002 Jan;9(1):53-6. PMID:11731805 doi:10.1038/nsb738