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Methionine synthase
From Proteopedia
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Revision as of 16:33, 2 April 2022
Contents |
Methionine synthase
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The change from homocysteine to methionine is one methyl group on N-5 donated from methyltetrahydrofolate (MTHF), a product of Methylenetetrahydrofolate reductase (MTHFR), with a protein-bound B-12 vitamin Cobalamin as the methyl carrier.
Vitamin B-12
Oxidation States of Cobalamin
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
- ↑ Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
- ↑ Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML. Domain alternation switches B(12)-dependent methionine synthase to the activation conformation. Nat Struct Biol. 2002 Jan;9(1):53-6. PMID:11731805 doi:10.1038/nsb738
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