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| | ==CED-2== | | ==CED-2== |
| - | <StructureSection load='3qwy' size='340' side='right' caption='[[3qwy]], [[Resolution|resolution]] 2.52Å' scene=''> | + | <StructureSection load='3qwy' size='340' side='right'caption='[[3qwy]], [[Resolution|resolution]] 2.52Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3qwy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QWY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3qwy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qwx|3qwx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qwx|3qwx]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ced-2, Y41D4B.13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ced-2, Y41D4B.13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwy OCA], [http://pdbe.org/3qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qwy RCSB], [http://www.ebi.ac.uk/pdbsum/3qwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwy ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwy OCA], [https://pdbe.org/3qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwy RCSB], [https://www.ebi.ac.uk/pdbsum/3qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwy ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CED2_CAEEL CED2_CAEEL]] Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).<ref>PMID:10707082</ref> <ref>PMID:11449278</ref> <ref>PMID:15744306</ref> <ref>PMID:1936965</ref> <ref>PMID:19402756</ref> <ref>PMID:6857247</ref> | + | [[https://www.uniprot.org/uniprot/CED2_CAEEL CED2_CAEEL]] Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).<ref>PMID:10707082</ref> <ref>PMID:11449278</ref> <ref>PMID:15744306</ref> <ref>PMID:1936965</ref> <ref>PMID:19402756</ref> <ref>PMID:6857247</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[Cell death protein|Cell death protein]] | + | *[[Cell death protein 3D structures|Cell death protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Caeel]] | | [[Category: Caeel]] |
| | + | [[Category: Large Structures]] |
| | [[Category: Hu, Y]] | | [[Category: Hu, Y]] |
| | [[Category: Kang, Y]] | | [[Category: Kang, Y]] |
| Structural highlights
Function
[CED2_CAEEL] Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).[1] [2] [3] [4] [5] [6]
Publication Abstract from PubMed
In the nematode Caenorhabditis elegans, the cell corpse engulfment proteins CED-2, CED-5, and CED-12 act in the same pathway to regulate the activation of the Rac small GTPase, CED-10, leading to the rearrangement of the actin cytoskeleton for engulfing apoptotic cells. Nevertheless, it is not well understood how these proteins act together. Here we report the crystal structures of the CED-2 protein as determined by X-ray crystallography. The full-length CED-2 protein and its truncated form containing the N-terminal SH2 domain and the first SH3 domain show similar three-dimensional structures. A CED-2 point mutation (F125G) disrupting its interaction with the PXXP motif of CED-5 did not affect its rescuing activity. However, CED-2 was found to interact with the N-terminal region of CED-5. Our findings suggest that CED-2 may regulate cell corpse engulfment by interacting with CED-5 through the N-terminal region rather than the PXXP motif.
Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.,Kang Y, Xu J, Liu Y, Sun J, Sun D, Hu Y, Liu Y Biochem Biophys Res Commun. 2011 May 17. PMID:21616056[7]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Reddien PW, Horvitz HR. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol. 2000 Mar;2(3):131-6. PMID:10707082 doi:http://dx.doi.org/10.1038/35004000
- ↑ Reddien PW, Cameron S, Horvitz HR. Phagocytosis promotes programmed cell death in C. elegans. Nature. 2001 Jul 12;412(6843):198-202. PMID:11449278 doi:http://dx.doi.org/10.1038/35084096
- ↑ Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, Schnabel R, Hengartner MO. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005 Mar 3;434(7029):93-9. PMID:15744306 doi:http://dx.doi.org/nature03263
- ↑ Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991 Sep;129(1):79-94. PMID:1936965
- ↑ Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, Horvitz HR. Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4):e99. doi: 10.1371/journal.pbio.1000099. PMID:19402756 doi:http://dx.doi.org/10.1371/journal.pbio.1000099
- ↑ Hedgecock EM, Sulston JE, Thomson JN. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science. 1983 Jun 17;220(4603):1277-9. PMID:6857247
- ↑ Kang Y, Xu J, Liu Y, Sun J, Sun D, Hu Y, Liu Y. Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem Biophys Res Commun. 2011 May 17. PMID:21616056 doi:10.1016/j.bbrc.2011.05.051
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