7vbt
From Proteopedia
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==Crystal structure of RIOK2 in complex with CQ211== | ==Crystal structure of RIOK2 in complex with CQ211== | ||
| - | <StructureSection load='7vbt' size='340' side='right'caption='[[7vbt]]' scene=''> | + | <StructureSection load='7vbt' size='340' side='right'caption='[[7vbt]], [[Resolution|resolution]] 2.54Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vbt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbt OCA], [https://pdbe.org/7vbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbt RCSB], [https://www.ebi.ac.uk/pdbsum/7vbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbt ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ZH:8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one'>5ZH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbt OCA], [https://pdbe.org/7vbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbt RCSB], [https://www.ebi.ac.uk/pdbsum/7vbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/RIOK2_HUMAN RIOK2_HUMAN]] Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).<ref>PMID:16037817</ref> <ref>PMID:19564402</ref> <ref>PMID:21880710</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Zhang ZM]] | [[Category: Zhang ZM]] | ||
[[Category: Zhu C]] | [[Category: Zhu C]] | ||
Revision as of 06:47, 8 September 2022
Crystal structure of RIOK2 in complex with CQ211
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