7r7j
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of RadD with ADP== | ==Crystal structure of RadD with ADP== | ||
| - | <StructureSection load='7r7j' size='340' side='right'caption='[[7r7j]]' scene=''> | + | <StructureSection load='7r7j' size='340' side='right'caption='[[7r7j]], [[Resolution|resolution]] 2.03Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R7J FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R7J FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r7j OCA], [https://pdbe.org/7r7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r7j RCSB], [https://www.ebi.ac.uk/pdbsum/7r7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r7j ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r7j OCA], [https://pdbe.org/7r7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r7j RCSB], [https://www.ebi.ac.uk/pdbsum/7r7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r7j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RADD_ECOLI RADD_ECOLI] May be a helicase. In combination with RadA is important in repair of double-strand DNA breaks (DSB) (PubMed:25425430, PubMed:25484163).<ref>PMID:25425430</ref> <ref>PMID:25484163</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging radiation. Precisely how RadD participates in genome maintenance remains unclear. Here we present a high-resolution X-ray crystal structure of ADP-bound Escherichia coli RadD, revealing a zinc-ribbon element that was not modelled in a previous RadD crystal structure. Insights into the mode of nucleotide binding and additional structure refinement afforded by the new RadD model will help to drive investigations into the activity of RadD as a genome stability and repair factor. | ||
| + | |||
| + | X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.,Osorio Garcia MA, Satyshur KA, Cox MM, Keck JL PLoS One. 2022 Apr 28;17(4):e0266031. doi: 10.1371/journal.pone.0266031., eCollection 2022. PMID:35482735<ref>PMID:35482735</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7r7j" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cox MM]] | [[Category: Cox MM]] | ||
Revision as of 06:25, 26 October 2022
Crystal structure of RadD with ADP
| |||||||||||
