|
|
| Line 1: |
Line 1: |
| | | | |
| | ==Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis== | | ==Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis== |
| - | <StructureSection load='4hrv' size='340' side='right' caption='[[4hrv]], [[Resolution|resolution]] 1.89Å' scene=''> | + | <StructureSection load='4hrv' size='340' side='right'caption='[[4hrv]], [[Resolution|resolution]] 1.89Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4hrv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HRV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4hrv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HRV FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gna1162 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrv OCA], [https://pdbe.org/4hrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hrv RCSB], [https://www.ebi.ac.uk/pdbsum/4hrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hrv ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrv OCA], [http://pdbe.org/4hrv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hrv RCSB], [http://www.ebi.ac.uk/pdbsum/4hrv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hrv ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q7BMM3_NEIME Q7BMM3_NEIME] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 21: |
Line 22: |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Cai, X]] | + | [[Category: Large Structures]] |
| - | [[Category: Lin, Z]] | + | [[Category: Neisseria meningitidis]] |
| - | [[Category: Shen, Y]] | + | [[Category: Cai X]] |
| - | [[Category: Duf799]] | + | [[Category: Lin Z]] |
| - | [[Category: Lipid binding protein]] | + | [[Category: Shen Y]] |
| Structural highlights
Function
Q7BMM3_NEIME
Publication Abstract from PubMed
GNA1162, a predicted lipoprotein from Neisseria meningitidis, is a potential candidate for a universal vaccine against meningococcal disease caused by N. meningitidis serogroup B. Here, the crystal structure of GNA1162 at 1.89 A resolution determined by single-wavelength anomalous dispersion (SAD) is reported. The structure of GNA1162 appears to be a dimer in the crystallographic asymmetric unit as well as in solution. The overall structure of the dimer indicates that each monomer inserts its C-terminal alpha5 helix into the hydrophobic groove of the other molecule. Moreover, the beta4 strands of each monomer lie antiparallel to each other and interact through multiple main-chain hydrogen bonds. Through structural comparisons and operon predictions, it is hypothesized that GNA1162 is part of a transport system and assists in transport and reassembly. The crystal structure of GNA1162 sheds light on its possible function and provides potentially valuable information for the design of a vaccine against meningococcal disease.
Structure of Neisseria meningitidis lipoprotein GNA1162.,Cai X, Lu J, Wu Z, Yang C, Xu H, Lin Z, Shen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):362-8. doi:, 10.1107/S1744309113004417. Epub 2013 Mar 28. PMID:23545639[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Cai X, Lu J, Wu Z, Yang C, Xu H, Lin Z, Shen Y. Structure of Neisseria meningitidis lipoprotein GNA1162. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):362-8. doi:, 10.1107/S1744309113004417. Epub 2013 Mar 28. PMID:23545639 doi:http://dx.doi.org/10.1107/S1744309113004417
|
