7w0v

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Current revision (20:06, 16 November 2022) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7w0v is ON HOLD until Paper Publication
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==C4'-SCF3-DT modifeid DNA-DNA duplex==
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<StructureSection load='7w0v' size='340' side='right'caption='[[7w0v]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7w0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Octodon_degus Octodon degus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=84E:[(2S,3S,5R)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-2-(trifluoromethylsulfanyl)oxolan-2-yl]methyl+dihydrogen+phosphate'>84E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0v OCA], [https://pdbe.org/7w0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0v RCSB], [https://www.ebi.ac.uk/pdbsum/7w0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0v ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fluorinated nucleotides are invaluable for (19) F NMR studies of nucleic acid structure and function. Here, we synthesized 4'-SCF3 -thymidine (T 4 ' - SCF 3 ${{^{4{^\prime}\hbox{-}{\rm SCF}{_{3}}}}}$ ) and incorporated it into DNA by means of solid-phase DNA synthesis. NMR studies showed that the 4'-SCF3 group exhibited a flexible orientation in the minor groove of DNA duplexes and was well accommodated by various higher order DNA structures. The three magnetically equivalent fluorine atoms in 4'-SCF3 -DNA constitute an isolated spin system, offering high (19) F NMR sensitivity and excellent resolution of the positioning of T 4 ' - SCF 3 ${{^{4{^\prime}\hbox{-}{\rm SCF}{_{3}}}}}$ within various secondary and tertiary DNA structures. The high structural adaptability and high sensitivity of T 4 ' - SCF 3 ${{^{4{^\prime}\hbox{-}{\rm SCF}{_{3}}}}}$ make it a valuable (19) F NMR probe for quantitatively distinguishing diverse DNA structures with single-nucleotide resolution and for monitoring the dynamics of interactions in the minor groove of double-stranded DNA.
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Authors:
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4'-SCF3 -Labeling Constitutes a Sensitive (19) F NMR Probe for Characterization of Interactions in the Minor Groove of DNA.,Li Q, Trajkovski M, Fan C, Chen J, Zhou Y, Lu K, Li H, Su X, Xi Z, Plavec J, Zhou C Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202201848. doi:, 10.1002/anie.202201848. Epub 2022 Oct 19. PMID:36163470<ref>PMID:36163470</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7w0v" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Octodon degus]]
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[[Category: Chen J]]
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[[Category: Fan C]]
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[[Category: Li H]]
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[[Category: Li Q]]
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[[Category: Lu K]]
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[[Category: Plavec J]]
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[[Category: Su X]]
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[[Category: Trajkovski M]]
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[[Category: Xi Z]]
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[[Category: Zhou C]]
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[[Category: Zhou Y]]

Current revision

C4'-SCF3-DT modifeid DNA-DNA duplex

PDB ID 7w0v

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