7x1r
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human thioredoxin reductase bound by Au== | |
| - | + | <StructureSection load='7x1r' size='340' side='right'caption='[[7x1r]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7x1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X1R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x1r OCA], [https://pdbe.org/7x1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x1r RCSB], [https://www.ebi.ac.uk/pdbsum/7x1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x1r ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao P]] | ||
| + | [[Category: Cao SH]] | ||
| + | [[Category: Gao XY]] | ||
| + | [[Category: Gong Y]] | ||
| + | [[Category: He B]] | ||
| + | [[Category: He ZS]] | ||
| + | [[Category: Jiang HD]] | ||
Revision as of 10:03, 14 December 2022
Cryo-EM structure of human thioredoxin reductase bound by Au
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Categories: Homo sapiens | Large Structures | Cao P | Cao SH | Gao XY | Gong Y | He B | He ZS | Jiang HD
