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4okm

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<StructureSection load='4okm' size='340' side='right'caption='[[4okm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4okm' size='340' side='right'caption='[[4okm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4okm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stre2 Stre2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4okm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_pristinaespiralis_ATCC_25486 Streptomyces pristinaespiralis ATCC 25486]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4okz|4okz]], [[1ps1|1ps1]], [[4mc0|4mc0]], [[4mc3|4mc3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okm OCA], [https://pdbe.org/4okm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okm RCSB], [https://www.ebi.ac.uk/pdbsum/4okm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SSDG_02809, ZP_06911744 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=457429 STRE2])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okm OCA], [http://pdbe.org/4okm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okm RCSB], [http://www.ebi.ac.uk/pdbsum/4okm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okm ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEDS_STRE2 SEDS_STRE2] Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene selina-4(15),7(11)-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP leading to a (E,E)-germacradienyl cation (PubMed:23307484, PubMed:24890698). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:23307484, PubMed:24890698).<ref>PMID:23307484</ref> <ref>PMID:24890698</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Squalene synthase]]
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[[Category: Streptomyces pristinaespiralis ATCC 25486]]
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[[Category: Stre2]]
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[[Category: Baer P]]
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[[Category: Baer, P]]
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[[Category: Citron CA]]
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[[Category: Citron, C A]]
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[[Category: Dickschat JS]]
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[[Category: Dickschat, J S]]
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[[Category: Fischer K]]
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[[Category: Fischer, K]]
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[[Category: Groll M]]
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[[Category: Groll, M]]
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[[Category: Klapschinski T]]
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[[Category: Klapschinski, T]]
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[[Category: Rabe P]]
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[[Category: Rabe, P]]
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[[Category: Cyclase]]
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[[Category: Induced fit]]
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[[Category: Open and closed conformation]]
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[[Category: Pyrophosphate sensor]]
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[[Category: Sesquiterpene]]
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[[Category: Terpenoid]]
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[[Category: Transferase]]
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Revision as of 07:30, 25 January 2023

Selinadiene Synthase apo and in complex with diphosphate

PDB ID 4okm

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