8gu3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Caenorhabditis elegans METT-10 methyltransferase domain== | |
| - | + | <StructureSection load='8gu3' size='340' side='right'caption='[[8gu3]], [[Resolution|resolution]] 3.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GU3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gu3 OCA], [https://pdbe.org/8gu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gu3 RCSB], [https://www.ebi.ac.uk/pdbsum/8gu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gu3 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MET16_CAEEL MET16_CAEEL] RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289). Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194). Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194). Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).<ref>PMID:19596901</ref> <ref>PMID:19752194</ref> <ref>PMID:33930289</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis elegans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ju J]] | ||
| + | [[Category: Tomita K]] | ||
Revision as of 11:25, 1 February 2023
Crystal structure of Caenorhabditis elegans METT-10 methyltransferase domain
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