4rbn

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<StructureSection load='4rbn' size='340' side='right'caption='[[4rbn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='4rbn' size='340' side='right'caption='[[4rbn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rbn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_nitrosomonas"_lehmann_and_neumann_1899 "bacterium nitrosomonas" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RBN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rbn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBN FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ss2, NE1214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=915 "Bacterium nitrosomonas" Lehmann and Neumann 1899])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbn OCA], [https://pdbe.org/4rbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbn RCSB], [https://www.ebi.ac.uk/pdbsum/4rbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbn ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sucrose_synthase Sucrose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.13 2.4.1.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbn OCA], [http://pdbe.org/4rbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rbn RCSB], [http://www.ebi.ac.uk/pdbsum/4rbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbn ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SUS_NITEU SUS_NITEU] Catalyzes the reversible conversion of sucrose and a nucleotide disphosphate (NDP) into fructose and NDP-glucose; although the reaction is freely reversible in vitro, the physiological reaction seems to be sucrose cleavage. Unlike characterized plant enzymes prefers ADP as a cosubstrate, whereas plants prefer UDP (PubMed:25846332, PubMed:26013491). The KM for sucrose is 8-fold lower in the presence of ADP than UDP (PubMed:25846332). Its preference for ADP over UDP suggests it may directly link sucrose and glycogen metabolism (Probable).<ref>PMID:25846332</ref> <ref>PMID:26013491</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacterium nitrosomonas lehmann and neumann 1899]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sucrose synthase]]
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[[Category: Nitrosomonas europaea]]
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[[Category: Ballicora, M A]]
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[[Category: Asencion Diez MD]]
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[[Category: Diez, M D.Asencion]]
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[[Category: Ballicora MA]]
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[[Category: Figueroa, C M]]
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[[Category: Figueroa CM]]
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[[Category: Iglesias, A A]]
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[[Category: Iglesias AA]]
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[[Category: Liu, D]]
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[[Category: Liu D]]
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[[Category: Machtey, M]]
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[[Category: Machtey M]]
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[[Category: Wu, R]]
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[[Category: Wu R]]
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[[Category: Cytosol]]
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[[Category: D-fructose]]
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[[Category: Glucosyltransferase]]
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[[Category: Ndp]]
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[[Category: Ndp-glucose]]
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[[Category: Rossmann fold]]
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[[Category: Sucrose]]
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[[Category: Transferase]]
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Revision as of 06:48, 2 March 2023

The crystal structure of Nitrosomonas europaea sucrose synthase: Insights into the evolutionary origin of sucrose metabolism in prokaryotes

PDB ID 4rbn

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