Sandbox Reserved 1792
From Proteopedia
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{{Template:CH462_Biochemistry_II_2023}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Template:CH462_Biochemistry_II_2023}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | == | + | ==Thyroid Stimulating Hormone Receptor (TSHR)== |
| - | <StructureSection load=' | + | <StructureSection load='7xw5' size='340' side='right' caption='The Human Thyroid Stimulating Hormone Receptor' scene=''> |
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == | + | == Introduction == |
| + | '''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T3] and [https://en.wikipedia.org/wiki/Thyroid_hormones T4] | ||
| - | + | [[Image:Thyroid System.png|400 px|left|thumb|An overview of the Thyroid System source: [https://en.wikipedia.org/wiki/Thyroid_hormones Thyroid Hormones]]] | |
| - | == | + | == Structure== |
| - | == | + | === Transmembrane Region=== |
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| + | === Hinge Region=== | ||
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| + | === Leucine Rich Domain=== | ||
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| + | === Binding Pocket=== | ||
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| + | == Active vs Inactive State=== | ||
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| + | == Specific Residues == | ||
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| + | == Biological Relevance == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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== References == | == References == | ||
<references/> | <references/> | ||
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| + | ==Student Contributors== | ||
| + | *Alex Kem | ||
| + | *Grace Lane | ||
Revision as of 16:54, 17 March 2023
| This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795. |
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Thyroid Stimulating Hormone Receptor (TSHR)
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Student Contributors
- Alex Kem
- Grace Lane
